Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31128494 | 0.87 | KDM4E (0.39) | NPC1RAB9AHSD17B10KDM4EALDH1A1 | |
| SCHEMBL18490099 | 0.80 | NOTUM (0.46) | NOTUMHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL31128612 | 0.78 | NOTUM (0.37) | NOTUMNPC1RAB9AHSD17B10KDM4E | |
| SCHEMBL31128547 | 0.77 | THRB (0.49) | NPC1RAB9AHSD17B10KDM4EALDH1A1 | |
| SCHEMBL31128567 | 0.77 | NOTUM (0.49) | NOTUMNPC1RAB9AKDM4EHPGD | |
| SCHEMBL8196656 | 0.75 | NOTUM (0.64) | NOTUMNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL31128570 | 0.73 | DCTPP1 (0.37) | NPC1RAB9AHSD17B10KDM4EALDH1A1 | |
| SCHEMBL31128598 | 0.73 | NOTUM (0.46) | NOTUMTHRBRXFP1 | |
| SCHEMBL31128525 | 0.71 | NOTUM (0.43) | NOTUMKDM4EHPGDMAPK1MAPT | |
| SCHEMBL7095254 | 0.71 | PGR (0.55) | KDM4EALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024173343-A1 | COMPOUNDS TARGETING HYDROXYSTEROID 17-BETA DEHYDROGENASE (HSD17B) AND USES THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2024-08-22 | — | — | WO | disclosed |