Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31128590 | 0.87 | RXFP1 (0.41) | CHRNB2CHRNA4THRBRXFP1KDM1A | |
| SCHEMBL31128516 | 0.77 | THRB (0.56) | THRBRXFP1 | |
| SCHEMBL8196656 | 0.76 | NOTUM (0.64) | NOTUM | |
| SCHEMBL4220273 | 0.75 | NOTUM (0.62) | NOTUMCHRNB2CHRNA4LRRK2CHEK1 | |
| SCHEMBL31128525 | 0.74 | NOTUM (0.43) | NOTUMCHRNB2CHRNA4LRRK2CHEK1 | |
| SCHEMBL31128596 | 0.73 | NOTUM (0.41) | NOTUMTHRBRXFP1 | |
| SCHEMBL31128567 | 0.73 | NOTUM (0.49) | NOTUMLRRK2CHEK1AURKADAPK3 | |
| SCHEMBL2763829 | 0.72 | NOTUM (0.53) | NOTUMLRRK2CHEK1AURKADAPK3 | |
| SCHEMBL24784637 | 0.70 | GRM5 (0.44) | KDM1ALRRK2GRM5 | |
| SCHEMBL30018769 | 0.70 | GRM5 (0.44) | KDM1ALRRK2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024173343-A1 | COMPOUNDS TARGETING HYDROXYSTEROID 17-BETA DEHYDROGENASE (HSD17B) AND USES THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2024-08-22 | — | — | WO | disclosed |