Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.44 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311402 | 0.87 | ATM (0.53) | EGFRKDM4ESMN1; SMN2HSD17B10CYP1A2 | |
| SCHEMBL312442 | 0.87 | BACE1 (0.62) | KDM4ELMNAGAASMN1; SMN2HSD17B10 | |
| SCHEMBL311962 | 0.86 | EGFR (0.47) | EGFRKDM4ELMNAGAASMN1; SMN2 | |
| SCHEMBL312410 | 0.86 | CYP3A4 (0.52) | KDM4ELMNASMN1; SMN2TP53CYP1A2 | |
| SCHEMBL312252 | 0.84 | AKR1B1 (0.46) | EGFRKDM4ELMNAGAASMN1; SMN2 | |
| SCHEMBL312740 | 0.84 | AKR1B1 (0.57) | KDM4ELMNAGAASMN1; SMN2HSD17B10 | |
| SCHEMBL10215485 | 0.82 | HPGD (0.59) | KDM4ELMNASMN1; SMN2HSD17B10TP53 | |
| SCHEMBL312506 | 0.81 | KDM4E (0.45) | KDM4ELMNAGAASMN1; SMN2HSD17B10 | |
| SCHEMBL312050 | 0.80 | KDM4E (0.44) | EGFRKDM4ELMNAGAASMN1; SMN2 | |
| SCHEMBL311828 | 0.78 | CYP2D6 (0.46) | EGFRKDM4ELMNASMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093273-B2 | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2012-01-10 | — | — | US | disclosed |
| EP-2332527-A2 | Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2011-06-15 | — | — | EP | disclosed |