Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.62 |
| ▸ | TYR | P14679 | 1/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.62 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.62 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | XDH | P47989 | 3/20 | 0.53 |
| ▸ | QPCT | Q16769 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311402 | 0.89 | ATM (0.53) | BACE1TYRPTPN1PTGS1PTPN12 | |
| SCHEMBL311334 | 0.87 | EGFR (0.46) | BACE1TYRPTPN1PTGS1PTPN12 | |
| SCHEMBL312740 | 0.86 | AKR1B1 (0.57) | ALDH1A1HPGDSMN1; SMN2LMNAKDM4E | |
| SCHEMBL312252 | 0.84 | AKR1B1 (0.46) | PTPN1ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL311962 | 0.84 | EGFR (0.47) | BACE1TYRPTPN1PTGS1PTPN12 | |
| SCHEMBL312410 | 0.84 | CYP3A4 (0.52) | ALDH1A1HPGDSMN1; SMN2LMNAKDM4E | |
| SCHEMBL10215485 | 0.82 | HPGD (0.59) | ALDH1A1HPGDSMN1; SMN2LMNAKDM4E | |
| SCHEMBL30142951 | 0.81 | KDM4E (0.56) | BACE1ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL311742 | 0.81 | BACE1 (0.62) | BACE1TYRPTPN1PTGS1PTPN12 | |
| SCHEMBL312477 | 0.80 | BACE1 (0.61) | BACE1TYRPTPN1PTGS1PTPN12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093273-B2 | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2012-01-10 | — | — | US | disclosed |
| EP-2332527-A2 | Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2011-06-15 | — | — | EP | disclosed |