Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 3/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CPA1 | P15085 | 2/20 | 0.36 |
| ▸ | CPB1 | P15086 | 1/20 | 0.36 |
| ▸ | CPA3 | P15088 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 4/20 | 0.35 |
| ▸ | MMP9 | P14780 | 3/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3113683 | 1.00 | CTSC (0.47) | CTSCADAMTS5SCN4AHTR2CHTR2B | |
| SCHEMBL27565204 | 0.90 | CTSC (0.47) | CTSCADAMTS5SCN4AHTR2CHTR2B | |
| SCHEMBL19412232 | 0.89 | CTSC (0.39) | CTSCADAMTS5SCN4AHTR2CHTR2B | |
| SCHEMBL7069746 | 0.87 | ADAMTS5 (0.46) | ADAMTS5KMT2AMMP9 | |
| SCHEMBL6429094 | 0.86 | CTSC (0.37) | CTSCADAMTS5SCN4AKMT2A | |
| SCHEMBL7071119 | 0.83 | ADAMTS5 (0.43) | CTSCADAMTS5KMT2AMMP9 | |
| SCHEMBL16598348 | 0.83 | ITGB1 (0.39) | CTSCKMT2A | |
| SCHEMBL19412130 | 0.82 | CTSC (0.37) | CTSCSCN4AHTR2CHTR2BKMT2A | |
| SCHEMBL19412214 | 0.82 | CTSC (0.37) | CTSCSCN4AHTR2CHTR2B | |
| SCHEMBL16598553 | 0.80 | ROCK2 (0.37) | CTSCKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987306-B2 | Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-03-24 | — | — | US | disclosed |
| US-20100179119-A1 | Inhibitors of Integrin Alpha2Beta1 Based on Prolyl Diaminopropionic Acid Scaffold | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179119-A1 | Inhibitors of Integrin Alpha2Beta1 Based on Prolyl Diaminopropionic Acid Scaffold | ITGA2B, ITGA2, ITGB2 | CTSC 957/4885ADAMTS5 1691/4885SCN4A 941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.