Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 3/20 | 0.32 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | FAP | Q12884 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3099384 | 0.94 | TACR1 (0.32) | PDK2 | |
| SCHEMBL1036065 | 0.94 | PDK2 (0.36) | PDK2 | |
| SCHEMBL3108150 | 0.94 | PDK2 (0.34) | PDK2GPR139MEN1KMT2AFAP | |
| SCHEMBL3113195 | 0.92 | PTGES (0.32) | MEN1KMT2AFAPTDP1 | |
| SCHEMBL119082 | 0.92 | PTGES (0.32) | MEN1KMT2AFAPTDP1 | |
| SCHEMBL29416682 | 0.92 | PTGES (0.32) | MEN1KMT2AFAPTDP1 | |
| SCHEMBL20117288 | 0.92 | PTGES (0.32) | MEN1KMT2AFAPTDP1 | |
| SCHEMBL3636982 | 0.91 | FAP (0.39) | PDK2MEN1KMT2AFAPTDP1 | |
| SCHEMBL3113552 | 0.91 | GPR139 (0.35) | GPR139MEN1KMT2AFAPTDP1 | |
| SCHEMBL3104838 | 0.91 | MEN1 (0.33) | MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3222618-B1 | NAPTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS | DU PONT (US) | 2020-09-09 | — | — | EP | disclosed |
| WO-2017176948-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED ISOXAZOLINE COMPOUNDS - CRYSTALLINE TOLUENE SOLVATE OF (S)-AFOXOLANER | MERIAL, INC. (US) | 2017-10-12 | — | — | WO | disclosed |
| EP-3222618-A1 | NAPTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS | E. I. du Pont de Nemours and Company (US) | 2017-09-27 | — | — | EP | disclosed |
| US-20140113943-A9 | Naphthalene Isoxazoline Invertebrate Pest Control Agents | E.I. DU PONT DE NEMOURS AND COMPANY | 2014-04-24 | — | — | US | disclosed |
| US-20130217736-A1 | Naphthalene Isoxazoline Invertebrate Pest Control Agents | DU PONT (US) | 2013-08-22 | — | — | US | disclosed |
| US-8410153-B2 | Naphthalene isoxazoline invertebrate pest control agents | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2013-04-02 | — | — | US | disclosed |
| US-20100254959-A1 | NAPHTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100254959-A1 | NAPHTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS | C1S, C1R, C9 | PDK2 2229/4885GPR139 1150/4885MEN1 2671/4885 |
| US-20130217736-A1 | Naphthalene Isoxazoline Invertebrate Pest Control Agents | C1S, C1R, C9 | PDK2 2229/4885GPR139 1150/4885MEN1 2671/4885 |
| US-20140113943-A9 | Naphthalene Isoxazoline Invertebrate Pest Control Agents | C1S, C1R, C9 | PDK2 2229/4885GPR139 1150/4885MEN1 2671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.