Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | FAP | Q12884 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | PREP | P48147 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3113195 | 1.00 | PTGES (0.32) | PTGESORAI1KMT2AKDM4EATM | |
| SCHEMBL29416682 | 1.00 | PTGES (0.32) | PTGESORAI1KMT2AKDM4EATM | |
| SCHEMBL20117288 | 1.00 | PTGES (0.32) | PTGESORAI1KMT2AKDM4EATM | |
| Afoxolaner SCHEMBL18054743 | 0.94 | PTGES (0.33) | PTGESHPGDPOLB | |
| Esafoxolaner SCHEMBL18054742 | 0.94 | PTGES (0.33) | PTGESHPGDPOLB | |
| Afoxolaner SCHEMBL119580 | 0.94 | PTGES (0.33) | PTGESHPGDPOLB | |
| Afoxolaner SCHEMBL29367347 | 0.94 | PTGES (0.33) | PTGESHPGDPOLB | |
| Afoxolaner SCHEMBL29358921 | 0.94 | PTGES (0.33) | PTGESHPGDPOLB | |
| SCHEMBL21168921 | 0.94 | LMNA (0.32) | PTGESORAI1KDM4EFAP | |
| Esafoxolaner SCHEMBL29413811 | 0.94 | PTGES (0.33) | PTGESHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3222618-A1 | NAPTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS | E. I. du Pont de Nemours and Company (US) | 2017-09-27 | — | — | EP | claimed |
| US-8962681-B2 | Use of aminoacetonitrile derivatives against endoparasites | ZOETIS LLC (US) | 2015-02-24 | — | — | US | claimed |
| WO-2013057624-A9 | USE OF AMINOACETONITRILE DERIVATIVES AGAINST ENDOPARASITES | ZOETIS LLC (US) | 2014-10-30 | — | — | WO | claimed |
| US-20140243408-A1 | USE OF AMINOACETONITRILE DERIVATIVES AGAINST ENDOPARASITES | ZOETIS SERVICES LLC | 2014-08-28 | — | — | US | claimed |
| EP-2768497-A1 | USE OF AMINOACETONITRILE DERIVATIVES AGAINST ENDOPARASITES | Zoetis LLC (US) | 2014-08-27 | — | — | EP | claimed |
| US-20140113943-A9 | Naphthalene Isoxazoline Invertebrate Pest Control Agents | E.I. DU PONT DE NEMOURS AND COMPANY | 2014-04-24 | — | — | US | claimed |
| US-20130217736-A1 | Naphthalene Isoxazoline Invertebrate Pest Control Agents | DU PONT (US) | 2013-08-22 | — | — | US | claimed |
| WO-2013057624-A1 | USE OF AMINOACETONITRILE DERIVATIVES AGAINST ENDOPARASITES | AH USA 42 LLC (US) | 2013-04-25 | — | — | WO | claimed |
| EP-2424347-A1 | PESTICIDE COMPOSITIONS AND APPLICATORS | BASF Corporation (US) | 2012-03-07 | — | — | EP | claimed |
| EP-2424370-A2 | FOAMABLE PESTICIDE COMPOSITIONS | BASF Corporation (US) | 2012-03-07 | — | — | EP | claimed |
| WO-2011147952-A1 | PESTICIDAL MIXTURES | BASF SE (DE) | 2011-12-01 | — | — | WO | claimed |
| US-7964204-B2 | Isoxazolines for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-06-21 | — | — | US | claimed |
| WO-2011025789-A2 | FOAMABLE PESTICIDE COMPOSITIONS AND METHODS OF APPLICATION | BASF CORPORATION (US) | 2011-03-03 | — | — | WO | claimed |
| EP-1973888-B1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | DU PONT (US) | 2011-01-26 | — | — | EP | claimed |
| US-20100254959-A1 | NAPHTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-10-07 | — | — | US | claimed |
| US-11324220-B2 | Process for the preparation of isoxazoline compounds | Boehringer Ingelheim Animal Health USA Inc. (US) | 2022-05-10 | — | — | US | disclosed |
| EP-3440062-B1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED ISOXAZOLINE COMPOUNDS - CRYSTALLINE TOLUENE SOLVATE OF (S)-AFOXOLANER | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2021-10-06 | — | — | EP | disclosed |
| EP-2158188-A2 | NAPHTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS | E. I. Du Pont de Nemours and Company (US) | 2010-03-03 | — | — | EP | disclosed |
| WO-2010003877-A1 | PESTICIDAL MIXTURES COMPRISING ISOXAZOLINE COMPOUNDS II | BASF SE (DE) | 2010-01-14 | — | — | WO | disclosed |
| WO-2009002809-A2 | NAPHTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100254959-A1 | NAPHTHALENE ISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS | C1S, C1R, C9 | PTGES 3867/4885ORAI1 2971/4885KMT2A 3444/4885 |
| US-20130217736-A1 | Naphthalene Isoxazoline Invertebrate Pest Control Agents | C1S, C1R, C9 | PTGES 3867/4885ORAI1 2971/4885KMT2A 3444/4885 |
| US-20140113943-A9 | Naphthalene Isoxazoline Invertebrate Pest Control Agents | C1S, C1R, C9 | PTGES 3867/4885ORAI1 2971/4885KMT2A 3444/4885 |
| US-11324220-B2 | Process for the preparation of isoxazoline compounds | CYP3A7, CYP3A4, CYP3A5 | PTGES 2136/4885ORAI1 3906/4885KMT2A 1079/4885 |
| US-20140243408-A1 | USE OF AMINOACETONITRILE DERIVATIVES AGAINST ENDOPARASITES | DDC, ARG1, NAT1 | PTGES 3567/4885ORAI1 3292/4885KMT2A 1507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.