Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4304078 | 0.89 | MAPK14 (0.43) | ALDH1A1MAPTL3MBTL1MAPK14KMT2A | |
| SCHEMBL4313368 | 0.88 | ALDH1A1 (0.43) | ALDH1A1MAPTL3MBTL1MAPK14TDO2 | |
| SCHEMBL4312756 | 0.88 | HDAC1 (0.47) | ALDH1A1MAPTL3MBTL1KMT2APKM | |
| SCHEMBL4310271 | 0.87 | ALDH1A1 (0.41) | ALDH1A1MAPTL3MBTL1MAPK14ROCK2 | |
| SCHEMBL3121013 | 0.86 | ALDH1A1 (0.40) | ALDH1A1MAPTL3MBTL1MAPK14KMT2A | |
| SCHEMBL3122360 | 0.85 | ALDH1A1 (0.59) | ALDH1A1MAPTL3MBTL1KMT2ANPC1 | |
| SCHEMBL4315207 | 0.85 | ALDH1A1 (0.45) | ALDH1A1MAPTL3MBTL1KMT2AROCK2 | |
| SCHEMBL3945339 | 0.84 | ALDH1A1 (0.42) | ALDH1A1MAPTL3MBTL1MAPK14KMT2A | |
| SCHEMBL4306692 | 0.84 | HDAC1 (0.42) | ALDH1A1MAPTL3MBTL1KMT2AROCK2 | |
| SCHEMBL7982425 | 0.84 | PKM (0.43) | ALDH1A1MAPTL3MBTL1MAPK14KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |