Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 10/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3118172 | 0.98 | ADORA2B (0.40) | ADORA2BADORA1ADORA3MPOALDH1A1 | |
| SCHEMBL837291 | 0.92 | ADORA2B (0.48) | ADORA2BADORA1ADORA3ADORA2A | |
| SCHEMBL837154 | 0.92 | ADORA2B (0.43) | ADORA2BADORA1ADORA3PCK1ADORA2A | |
| SCHEMBL874355 | 0.92 | ADORA2B (0.44) | ADORA2BADORA1ADORA3PCK1ADORA2A | |
| SCHEMBL837752 | 0.91 | ADORA2B (0.44) | ADORA2BADORA1ADORA3PCK1ADORA2A | |
| SCHEMBL834086 | 0.91 | ADORA2B (0.39) | ADORA2BADORA1ADORA3PCK1ADORA2A | |
| SCHEMBL2533939 | 0.91 | ADORA2B (0.39) | ADORA2BADORA1ADORA3PCK1ADORA2A | |
| SCHEMBL836299 | 0.91 | ADORA2B (0.39) | ADORA2BADORA1ADORA3PCK1ADORA2A | |
| SCHEMBL837212 | 0.90 | ADORA2B (0.39) | ADORA2BADORA1ADORA3ADORA2A | |
| SCHEMBL3118132 | 0.90 | ADORA2B (0.38) | ADORA2BADORA1ADORA3PCK1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | XDH, GPR84, GPR88 | ADORA2B 111/4885ADORA1 32/4885ADORA3 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.