SCHEMBL31190811

SCHEMBL31190811

[2H]C([2H])([2H])C(F)(F)c1ccc(S(=O)(=O)Cl)cc1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.40
HSD17B10 Q99714 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
HSD11B1 P28845 9/20 0.37
KIF11 P52732 1/20 0.35
BCHE P06276 1/20 0.34
ACHE P22303 1/20 0.34
CA1 P00915 2/20 0.33
CA2 P00918 2/20 0.33
OXTR P30559 1/20 0.33
AVPR1A P37288 1/20 0.33
USP2 O75604 1/20 0.33
ALOX15 P16050 1/20 0.33
HTT P42858 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
PTGS2 P35354 1/20 0.33
CA5A P35218 1/20 0.32
CA9 Q16790 1/20 0.32
AKR1B1 P15121 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31190709 0.86 ALDH1A1 (0.44) ALDH1A1HSD17B10TDP1HSD11B1KIF11
SCHEMBL3227670 0.80 ALDH1A1 (0.45) ALDH1A1HSD17B10TDP1HSD11B1BCHE
SCHEMBL1085985 0.78 HSD11B1 (0.56) ALDH1A1HSD17B10TDP1HSD11B1KIF11
SCHEMBL61336 0.77 KIF11 (0.55) ALDH1A1HSD17B10TDP1HSD11B1KIF11
SCHEMBL17079544 0.74 ALDH1A1 (0.44) ALDH1A1HSD17B10TDP1HSD11B1KIF11
SCHEMBL1032223 0.73 ALDH1A1 (0.40) ALDH1A1HSD17B10TDP1HSD11B1KIF11
SCHEMBL66108 0.73 ALDH1A1 (0.61) ALDH1A1HSD17B10TDP1HSD11B1ACHE
SCHEMBL3041567 0.73 ALDH1A1 (0.48) ALDH1A1HSD17B10TDP1HSD11B1CA1
SCHEMBL3071920 0.72 KIF11 (0.66) KIF11PTGS2
Methylene Chloride SCHEMBL3042021 0.72 KIF11 (0.50) ALDH1A1HSD17B10TDP1HSD11B1KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024220747-A2 FLUORINATED CYCLIC DERIVATIVES OF SULFONAMIDES AND SULFONES, AND COMPOSITIONS AND METHODS THEREOF Lysoway Therapeutics, Inc. (US) 2024-10-24 WO disclosed