Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 3/20 | 0.32 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 2/20 | 0.31 |
| ▸ | MMP3 | P08254 | 2/20 | 0.31 |
| ▸ | MMP7 | P09237 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31228383 | 0.92 | MMP13 (0.39) | MMP13ALDH1A1MAPK1CCR5BMP1 | |
| SCHEMBL31228519 | 0.84 | ALDH1A1 (0.31) | ALDH1A1NPSR1MEN1RAB9AKMT2A | |
| SCHEMBL31228505 | 0.83 | KLK7 (0.36) | MMP13L3MBTL1CCR5MEN1RAB9A | |
| SCHEMBL31228376 | 0.80 | MMP13 (0.38) | MMP13NPSR1CCR5MEN1KMT2A | |
| SCHEMBL31228678 | 0.80 | MMP13 (0.37) | MMP13NPSR1CCR5MEN1RAB9A | |
| SCHEMBL31228300 | 0.80 | MMP13 (0.40) | MMP13CCR5STAT3MEN1KMT2A | |
| SCHEMBL31228306 | 0.80 | MMP13 (0.40) | MMP13CCR5STAT3MEN1KMT2A | |
| SCHEMBL31228367 | 0.79 | MMP13 (0.40) | MMP13CCR5STAT3MEN1KMT2A | |
| SCHEMBL31228374 | 0.76 | P2RX7 (0.42) | ALDH1A1MAPK1NPSR1L3MBTL1CCR5 | |
| SCHEMBL31228239 | 0.75 | MMP13 (0.39) | MMP13NPSR1L3MBTL1CCR5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |