Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 4-Chlorophenylbiguanide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Chlorophenylbiguanide SCHEMBL305068 | 0.84 | NPC1 (0.53) | ALDH1A1NPC1MAPTGAAHPGD | |
| 4-Chlorophenylbiguanide SCHEMBL28036618 | 0.83 | NPC1 (0.52) | ALDH1A1NPC1MAPTGAAHPGD | |
| 4-Chlorophenylbiguanide SCHEMBL3675607 | 0.83 | NPC1 (0.52) | ALDH1A1NPC1MAPTGAAHPGD | |
| 4-Chlorophenylbiguanide SCHEMBL3357690 | 0.81 | LMNA (0.48) | ALDH1A1NPC1MAPTGAAHPGD | |
| 4-Chlorophenylbiguanide SCHEMBL7207570 | 0.80 | NPC1 (0.48) | ALDH1A1NPC1MAPTGAAHPGD | |
| 4-Chlorophenylbiguanide SCHEMBL27542332 | 0.79 | LMNA (0.47) | ALDH1A1NPC1MAPTGAAHPGD | |
| SCHEMBL4113103 | 0.78 | NPC1 (0.66) | ALDH1A1NPC1MAPTGAAHPGD | |
| Chlorhexidine SCHEMBL2297671 | 0.78 | ALDH1A1 (0.51) | ALDH1A1POLBNPC1ITGB3ITGA2B | |
| Chlorhexidine SCHEMBL245334 | 0.78 | ALDH1A1 (0.51) | ALDH1A1POLBNPC1ITGB3ITGA2B | |
| Chlorhexidine SCHEMBL2764118 | 0.77 | ALDH1A1 (0.48) | ALDH1A1POLBHTTEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119948604-A | Treatment liquid for semiconductor manufacture, method for cleaning object to be treated, and method for manufacturing semiconductor | 富士胶片株式会社 | 2025-05-06 | — | — | CN | disclosed |
| CN-118922917-A | Composition, method for manufacturing semiconductor element, and method for cleaning semiconductor substrate | 富士胶片株式会社 | 2024-11-08 | — | — | CN | disclosed |