Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Chlorhexidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorhexidine SCHEMBL245334 | 1.00 | ALDH1A1 (0.51) | ALDH1A1POLBFOLH1HDAC8CNR1 | |
| Chlorhexidine SCHEMBL247291 | 0.93 | CNR1 (0.46) | ALDH1A1POLBFOLH1HDAC8CNR1 | |
| Chlorhexidine SCHEMBL4173718 | 0.93 | CNR1 (0.48) | ALDH1A1POLBFOLH1HDAC8CNR1 | |
| Chlorhexidine SCHEMBL15874034 | 0.92 | ALDH1A1 (0.47) | ALDH1A1POLBFOLH1HDAC8SLC6A3 | |
| Chlorhexidine SCHEMBL9420015 | 0.92 | ALDH1A1 (0.46) | ALDH1A1POLBFOLH1HDAC8CNR1 | |
| Chlorhexidine SCHEMBL2152457 | 0.92 | CNR1 (0.47) | ALDH1A1POLBFOLH1HDAC8CNR1 | |
| Chlorhexidine SCHEMBL4250265 | 0.92 | SMN1; SMN2 (0.45) | ALDH1A1POLBFOLH1HDAC8CNR1 | |
| Chlorhexidine SCHEMBL247105 | 0.91 | LMNA (0.45) | ALDH1A1POLBFOLH1HDAC8CNR1 | |
| Chlorhexidine SCHEMBL2975314 | 0.90 | CNR1 (0.48) | ALDH1A1POLBFOLH1HDAC8CNR1 | |
| Chlorhexidine SCHEMBL12044 | 0.90 | CNR1 (0.48) | ALDH1A1POLBFOLH1HDAC8CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011103440-A1 | SKIN DISINFECTANT COMPOSITION AND METHODS FOR MANUFACTURING AND USING | SKINVISIBLE PHARMACEUTICALS, INC. (US) | 2011-08-25 | — | — | WO | disclosed |
| US-20110207832-A1 | SKIN DISINFECTANT COMPOSITION AND METHODS FOR MANUFACTURING AND USING | SKINVISIBLE PHARMACEUTICALS, INC. (US) | 2011-08-25 | — | — | US | disclosed |
| US-20070160559-A1 | Skin disinfectant composition and methods for using | SKINVISIBLE PHARMACEUTICALS, INC. | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070160559-A1 | Skin disinfectant composition and methods for using | CUTA, DSG1, POLR1C | ALDH1A1 820/4885POLB 62/4885FOLH1 4141/4885 |
| US-20110207832-A1 | SKIN DISINFECTANT COMPOSITION AND METHODS FOR MANUFACTURING AND USING | CUTA, POLL, POLR1C | ALDH1A1 353/4885POLB 27/4885FOLH1 4558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.