Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 4/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13521724 | 0.90 | MAPT (0.49) | ADORA2BADORA2AGRIN1GRIN2BMAPT | |
| SCHEMBL13521574 | 0.87 | TP53 (0.44) | GRIN1GRIN2BMAPTLMNATP53 | |
| SCHEMBL3114848 | 0.87 | GRIN1 (0.43) | ADORA2BADORA2AGRIN1GRIN2BMAPT | |
| SCHEMBL3118576 | 0.86 | CES2 (0.49) | ADORA2BADORA2AGRIN1GRIN2BMAPT | |
| SCHEMBL13521612 | 0.85 | MAPT (0.51) | ADORA2BADORA2AMAPTLMNATP53 | |
| SCHEMBL3129349 | 0.85 | GRIN1 (0.48) | GRIN1GRIN2BLMNA | |
| SCHEMBL3129279 | 0.81 | KMT2A (0.50) | MAPTLMNATP53HTT | |
| SCHEMBL3244764 | 0.79 | PKM (0.46) | GRIN1GRIN2BMAPTHTT | |
| SCHEMBL3131888 | 0.79 | HSD17B10 (0.49) | GRIN1GRIN2BMAPTLMNATP53 | |
| SCHEMBL3128744 | 0.78 | GRIN1 (0.43) | GRIN1GRIN2BHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | claimed |