Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3114848 | 0.85 | GRIN1 (0.43) | TP53LMNAMAPT | |
| SCHEMBL3118576 | 0.84 | CES2 (0.49) | TP53MAPTPOLB | |
| SCHEMBL3129349 | 0.83 | GRIN1 (0.48) | LMNASMN1; SMN2GAA | |
| SCHEMBL13521724 | 0.83 | MAPT (0.49) | TP53HTTSMN1; SMN2MAPTPOLB | |
| SCHEMBL3123200 | 0.81 | ADORA2B (0.39) | TP53HTTLMNAMAPT | |
| SCHEMBL13521612 | 0.81 | MAPT (0.51) | TP53HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL3244764 | 0.79 | PKM (0.46) | KMT2AMEN1HTTSMN1; SMN2MAPT | |
| SCHEMBL13521623 | 0.77 | GRIN1 (0.49) | HTTPOLB | |
| SCHEMBL13521710 | 0.77 | GRIN1 (0.53) | TP53POLB | |
| SCHEMBL3127562 | 0.76 | GRIN1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | claimed |