Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 14/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 14/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3114848 | 0.91 | GRIN1 (0.43) | GRIN1GRIN2BLMNA | |
| SCHEMBL13521574 | 0.91 | TP53 (0.44) | GRIN1GRIN2BLMNA | |
| SCHEMBL3118576 | 0.90 | CES2 (0.49) | GRIN1GRIN2B | |
| SCHEMBL13521724 | 0.88 | MAPT (0.49) | GRIN1GRIN2BSMN1; SMN2 | |
| SCHEMBL3123200 | 0.85 | ADORA2B (0.39) | GRIN1GRIN2BLMNA | |
| SCHEMBL13521612 | 0.84 | MAPT (0.51) | LMNAF2SMN1; SMN2 | |
| SCHEMBL3129279 | 0.83 | KMT2A (0.50) | LMNAGAASMN1; SMN2 | |
| SCHEMBL3244764 | 0.83 | PKM (0.46) | GRIN1GRIN2BSMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL3131888 | 0.82 | HSD17B10 (0.49) | GRIN1GRIN2BLMNA | |
| SCHEMBL13521710 | 0.82 | GRIN1 (0.53) | GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | claimed |
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | disclosed |