Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.60 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.57 |
| ▸ | PLAU | P00749 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | WNT3A | P56704 | 1/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | GHSR | Q92847 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4530179 | 0.83 | LMNA (0.83) | TOP2ATOP2BLMNAMAPTHTT | |
| SCHEMBL3118874 | 0.82 | MGLL (0.61) | MAPTROCK2TSHRWNT3ACIT | |
| SCHEMBL13356363 | 0.81 | MAPT (0.80) | TOP2ATOP2BLMNAMAPTHTT | |
| SCHEMBL3127087 | 0.81 | ROCK2 (0.73) | MAPTHTTROCK2CITRAB9A | |
| SCHEMBL10198474 | 0.77 | MAPT (0.77) | LMNAMAPTHTTPLAUGAA | |
| SCHEMBL28551231 | 0.76 | MAPT (0.71) | TOP2ATOP2BLMNAMAPTHTT | |
| SCHEMBL30134465 | 0.76 | MAPT (0.64) | LMNAMAPTHTTPLAUGAA | |
| SCHEMBL29040342 | 0.75 | TOP2A (1.00) | TOP2ATOP2BLMNAMAPTHTT | |
| SCHEMBL3061430 | 0.75 | MAPT (1.00) | LMNAMAPTHTTGAATSHR | |
| SCHEMBL2203781 | 0.74 | LMNA (1.00) | LMNAMAPTHTTGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |