Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.49 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Naphthalenylthiazole SCHEMBL272929 | 0.83 | RAB9A (0.53) | CYP2A6LMNAKDM4ERAB9APDPK1 | |
| SCHEMBL6651731 | 0.82 | PRKCZ (0.47) | MAPK8MAPK10MAPK9CYP2A6CYP1A2 | |
| SCHEMBL26259560 | 0.80 | PDPK1 (0.54) | CYP2A6CYP1A2RAB9APDPK1HSP90AA1 | |
| SCHEMBL6240424 | 0.78 | LMNA (0.63) | IKBKETBK1LMNACYP1A2CYP3A4 | |
| SCHEMBL26259717 | 0.75 | HSD17B10 (0.54) | MAPK8MAPK10CYP2A6KDM4ERAB9A | |
| SCHEMBL6968376 | 0.75 | KDM4E (0.47) | IKBKETBK1CYP2A6LMNACYP1A2 | |
| SCHEMBL4722041 | 0.75 | RAB9A (0.49) | CYP2A6CYP1A2RAB9APDPK1HSP90AA1 | |
| SCHEMBL13537223 | 0.73 | IKBKE (0.54) | IKBKETBK1CYP2A6LMNACYP1A2 | |
| SCHEMBL26259375 | 0.73 | PDPK1 (0.59) | CYP2A6KDM4ERAB9APDPK1HSP90AA1 | |
| SCHEMBL19756681 | 0.73 | PDPK1 (0.46) | CYP2A6RAB9APDPK1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |