Sugi Predict

Sugi Predict / Compounds / SCHEMBL4722041

SCHEMBL4722041

SCHEMBL4722041

c1ccc2cc3c(-c4nccs4)cccc3cc2c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 1/20 0.49
▸ PDPK1 O15530 1/20 0.46
▸ SYK P43405 4/20 0.45
▸ AR P10275 1/20 0.42
▸ ADORA2A P29274 1/20 0.40
▸ ADORA1 P30542 1/20 0.40
▸ HSP90AA1 P07900 1/20 0.40
▸ CYP1A1 P04798 3/20 0.39
▸ CYP1A2 P05177 3/20 0.39
▸ CYP1B1 Q16678 3/20 0.39
▸ ADRA1A P35348 2/20 0.38
▸ SRC P12931 1/20 0.38
▸ CDK2 P24941 1/20 0.38
▸ ZAP70 P43403 1/20 0.38
▸ ADRA1D P25100 1/20 0.38
▸ ADRA1B P35368 1/20 0.38
▸ HSD17B10 Q99714 1/20 0.38
▸ LOXL2 Q9Y4K0 1/20 0.38
▸ CYP2A6 P11509 1/20 0.38
▸ ADRA2A P08913 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
1-Naphthalenylthiazole SCHEMBL272929 0.84 RAB9A (0.53) RAB9APDPK1SYKARADORA2A
SCHEMBL26259560 0.82 PDPK1 (0.54) RAB9APDPK1SYKARADORA2A
SCHEMBL26259375 0.78 PDPK1 (0.59) RAB9APDPK1SYKARADORA2A
SCHEMBL5692672 0.78 PDPK1 (0.64) RAB9APDPK1ADORA2AADORA1HSP90AA1
SCHEMBL26259717 0.77 HSD17B10 (0.54) RAB9APDPK1ARADORA2AADORA1
SCHEMBL1951149 0.76 PDPK1 (0.61) RAB9APDPK1ADORA2AADORA1HSP90AA1
SCHEMBL3124010 0.75 MAPK8 (0.49) RAB9APDPK1ARHSP90AA1CYP1A2
SCHEMBL15223441 0.75 PDPK1 (0.41) RAB9APDPK1SYKARADORA2A
SCHEMBL15223481 0.75 PDPK1 (0.41) RAB9APDPK1SYKARADORA2A
SCHEMBL31525868 0.75 PTPN1 (0.50) RAB9AAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107074765-B Organic molecules for organic opto-electronic devices 西诺拉股份有限公司 2021-05-25 — — CN disclosed
CN-107925004-A Organic molecule for organic electro-optic device 西诺拉股份有限公司 2018-04-17 — — CN disclosed
CN-107074765-A Organic molecules for organic opto-electronic devices 西诺拉股份有限公司 2017-08-18 — — CN disclosed
US-20080200475-A1 4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors PFIZER INC. 2008-08-21 — — US disclosed
US-20080194590-A1 4-Piperazinylthieno [2,3-D] Pyrimidine Compounds as Platelet Aggregation Inhibitors PFIZER INC 2008-08-14 — — US disclosed
US-20080176857-A1 4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors PFIZER INC. 2008-07-24 — — US disclosed
EP-1896483-A2 4-PIPERAZINYLTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS Pharmacia & Upjohn Company LLC (US) 2008-03-12 — — EP disclosed
EP-1874780-A1 4-PIPERAZINYLTHIENO[2,3-D]PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS Pharmacia & Upjohn Company LLC (US) 2008-01-09 — — EP disclosed
EP-1869051-A1 4-PIPERAZINYLTHIENO Ý2,3-D¨PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS Pharmacia & Upjohn Company LLC (US) 2007-12-26 — — EP disclosed
EP-1866317-A1 4-PIPERAZINOTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS Pharmacia & Upjohn Company LLC (US) 2007-12-19 — — EP disclosed
EP-1844052-A1 THIENO[2,3-D]PYRIMIDINE COMPOUNDS AS INHIBITORS OF ADP-MEDIATED PLATELETS AGGREGATION Pharmacia & Upjohn Company LLC (US) 2007-10-17 — — EP disclosed
WO-2006103544-A2 4-PIPERAZINYLTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS PHARMACIA & UPJOHN COMPANY LLC (US) 2006-10-05 — — WO disclosed
WO-2006103555-A1 4-PIPERAZINOTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS PHARMACIA & UPJOHN COMPANY LLC (US) 2006-10-05 — — WO disclosed
WO-2006103545-A1 4-PIPERAZINYLTHIENO [2,3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS PHARMACIA & UPJOHN COMPANY LLC (US) 2006-10-05 — — WO disclosed
WO-2006100591-A1 4-PIPERAZINNYLTHIENO [2,3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS PHARMACIA & UPJOHN COMPANY LLC (US) 2006-09-28 — — WO disclosed
WO-2006079916-A1 THIENO [2,3-D] PYRIMIDINE COMPOUNDS AS INHIBITORS OF ADP-MEDIATED PLATELETS AGGREGATION PHARMACIA & UPJOHN COMPANY LLC (US) 2006-08-03 — — WO disclosed
CN-1521692-A Ic card, ic card manufacturing method, ic card manufacturing apparatus and ic card judgement system ���Ῠ���ܴ�ع���ʽ���� 2004-08-18 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080176857-A1 4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors TBXA2R, P2RY4, PF4 RAB9A 2943/4885PDPK1 1658/4885SYK 737/4885
US-20080194590-A1 4-Piperazinylthieno [2,3-D] Pyrimidine Compounds as Platelet Aggregation Inhibitors PFKP, PF4, P2RY4 RAB9A 2275/4885PDPK1 372/4885SYK 344/4885
US-20080200475-A1 4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors PF4, TBXA2R, P2RY4 RAB9A 2647/4885PDPK1 2529/4885SYK 329/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.