SCHEMBL31248757

SCHEMBL31248757

Cc1cc2c(Br)cc(OC(F)(F)F)cc2n(C)c1=O

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ HIF1A Q16665 1/20 0.34
▸ DDR1 Q08345 4/20 0.33
▸ EGFR P00533 1/20 0.33
▸ BRPF1 P55201 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ PIK3CA P42336 1/20 0.32
▸ PRKDC P78527 1/20 0.32
▸ TDP2 O95551 1/20 0.32
▸ MAT2A P31153 1/20 0.32
▸ ALOX5 P09917 1/20 0.31
▸ IDO1 P14902 1/20 0.31
▸ ATM Q13315 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31248652 0.92 MEN1 (0.34) SMN1; SMN2MEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL26547632 0.84 CYP19A1 (0.43) MEN1KMT2AL3MBTL1ALDH1A1EGFR
SCHEMBL31248756 0.83 MEN1 (0.34) SMN1; SMN2MEN1KMT2AL3MBTL1EGFR
SCHEMBL31248639 0.81 KMT2A (0.34) MEN1KMT2AL3MBTL1ALDH1A1EGFR
SCHEMBL26547726 0.81 KMT2A (0.34) MEN1KMT2AL3MBTL1ALDH1A1EGFR
SCHEMBL31248637 0.79 BRPF1 (0.43) MEN1KMT2AL3MBTL1ALDH1A1EGFR
SCHEMBL26547732 0.77 ACACB (0.38) MEN1KMT2AL3MBTL1ALDH1A1EGFR
SCHEMBL26547697 0.76 ALDH1A1 (0.36) MEN1KMT2AL3MBTL1ALDH1A1HIF1A
SCHEMBL31426258 0.76 BRPF1 (0.40) SMN1; SMN2MEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL26547742 0.76 BRPF1 (0.40) SMN1; SMN2MEN1KMT2AL3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4720057-A2 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF Oncopia Therapeutics, Inc. D/B/A SK Life Science Labs (US) 2026-04-08 — — EP disclosed
WO-2024249888-A2 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF ONCOPIA THERAPEUTICS, INC. D/B/A SK LIFE SCIENCE LABS (US) 2024-12-05 — — WO disclosed
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