Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31258111 | 0.86 | MTNR1A (0.56) | MTNR1ATP53LMNAGABRA1GABRB2 | |
| SCHEMBL31258122 | 0.86 | MTNR1A (0.56) | MTNR1ATP53LMNAGABRA1GABRB2 | |
| Hydrochloric Acid SCHEMBL31258028 | 0.84 | MTNR1A (0.55) | MTNR1ATP53LMNAGABRA1GABRB2 | |
| SCHEMBL19281913 | 0.78 | DRD2 (0.62) | MTNR1AALDH1A1 | |
| SCHEMBL10225793 | 0.76 | DRD2 (0.50) | MTNR1A | |
| SCHEMBL6678060 | 0.74 | ITGB2 (0.39) | TP53LMNAALDH1A1ALOX12SMN1; SMN2 | |
| SCHEMBL16547295 | 0.74 | ALOX12 (0.46) | MTNR1ALMNAGABRA1GABRB2NPC1 | |
| SCHEMBL13054558 | 0.74 | GABRA1 (0.50) | MTNR1ATP53LMNAGABRA1GABRB2 | |
| SCHEMBL3716710 | 0.72 | GSK3B (0.48) | MTNR1ANPC1RAB9AMAPTKDM4E | |
| SCHEMBL29845506 | 0.72 | GSK3B (0.48) | MTNR1ANPC1RAB9AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4698529-A1 | BLOOD BRAIN BARRIER PENETRATING SELECTIVE INHIBITORS OF ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2026-02-25 | — | — | EP | disclosed |
| WO-2024220173-A1 | BLOOD BRAIN BARRIER PENETRATING SELECTIVE INHIBITORS OF ROCK2 PROTEIN KINASES AND USES THEREOF | Genosco Inc. (US) | 2024-10-24 | — | — | WO | disclosed |