Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | YAP1 | P46937 | 2/20 | 0.40 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29402224 | 0.90 | ITGB3 (0.42) | NPC1RAB9AITGB3ITGA2B | |
| SCHEMBL29398294 | 0.90 | ITGB3 (0.46) | EPHX2ITGB3ITGA2B | |
| SCHEMBL6927349 | 0.90 | ITGB3 (0.46) | EPHX2ITGB3ITGA2B | |
| SCHEMBL6942693 | 0.87 | LDHA (0.54) | ITGB3ITGA2BLDHA | |
| SCHEMBL3776724 | 0.87 | LDHA (0.54) | ITGB3ITGA2BLDHA | |
| SCHEMBL3638571 | 0.79 | LDHA (0.46) | LDHA | |
| SCHEMBL10785304 | 0.78 | MMP13 (0.43) | ITGB3ITGA2BLDHAALDH1A1 | |
| SCHEMBL3777215 | 0.77 | LDHA (0.46) | SMN1; SMN2CYP1A2CYP2D6CYP2C19LDHA | |
| SCHEMBL31407616 | 0.77 | LDHA (0.46) | SMN1; SMN2LDHAALDH1A1 | |
| SCHEMBL2292028 | 0.76 | MMP13 (0.57) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4727552-A2 | PASSIVE PERMEABLE PCSK9 ANTAGONIST COMPOUNDS | Merck Sharp & Dohme LLC (US) | 2026-04-22 | — | — | EP | disclosed |
| WO-2024259310-A2 | PASSIVE PERMEABLE PCSK9 ANTAGONIST COMPOUNDS | MERCK SHARP & DOHME LLC (US) | 2024-12-19 | — | — | WO | disclosed |