Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25381943 | 0.89 | MAPT (0.60) | MAPTMAPK1KMT2AALDH1A1LMNA | |
| SCHEMBL20722247 | 0.89 | MAPT (0.60) | MAPTMAPK1KMT2AALDH1A1LMNA | |
| SCHEMBL20722208 | 0.89 | MAPT (0.60) | MAPTMAPK1KMT2AALDH1A1LMNA | |
| SCHEMBL6534784 | 0.85 | MAPT (0.57) | MAPTMAPK1KMT2AALDH1A1LMNA | |
| SCHEMBL11047147 | 0.84 | MAPT (0.56) | MAPTMAPK1KMT2AALDH1A1LMNA | |
| SCHEMBL20912969 | 0.83 | MAPT (0.58) | MAPTMAPK1KMT2AALDH1A1LMNA | |
| SCHEMBL117759 | 0.83 | MAPT (0.58) | MAPTMAPK1KMT2AALDH1A1LMNA | |
| SCHEMBL117760 | 0.83 | MAPT (0.58) | MAPTMAPK1KMT2AALDH1A1LMNA | |
| SCHEMBL12980679 | 0.83 | MAPT (0.58) | MAPTMAPK1KMT2AALDH1A1LMNA | |
| SCHEMBL23365822 | 0.83 | MAPT (0.58) | MAPTMAPK1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9937157-B2 | Modified release dosage forms of xanthine oxidoreductase inhibitor or xanthine oxidase inhibitors | TAKEDA PHARMACEUTICALS U.S.A., INC. (US) | 2018-04-10 | — | — | US | disclosed |
| EP-2582812-B1 | NOVEL MODIFIED RELEASE DOSAGE FORMS OF XANTHINE OXIDOREDUCTASE INHIBITOR OR XANTHINE OXIDASE INHIBITORS | TAKEDA PHARMACEUTICALS USA INC (US) | 2018-01-24 | — | — | EP | disclosed |
| US-20160317505-A1 | NOVEL MODIFIED RELEASE DOSAGE FORMS OF XANTHINE OXIDOREDUCTASE INHIBITOR OR XANTHINE OXIDASE INHIBITORS | TAKEDA PHARMACEUTICALS U.S.A., INC. (US) | 2016-11-03 | — | — | US | disclosed |
| US-9248119-B2 | Modified release dosage forms of xanthine oxidoreductase inhibitor or xanthine oxidase inhibitors | TAKEDA PHARMACEUTICALS U.S.A., INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-9107912-B2 | Methods for concomitant treatment of theophylline and febuxostat | TAKEDA PHARMACEUTICALS U.S.A., INC. (US) | 2015-08-18 | — | — | US | disclosed |
| EP-2613780-B1 | METHODS FOR CONCOMITANT TREATMENT OF THEOPHYLLINE AND FEBUXOSTAT | TAKEDA PHARMACEUTICALS USA INC (US) | 2014-11-12 | — | — | EP | disclosed |
| US-20140329868-A1 | METHODS FOR TREATING HYPERTENSION | TAKEDA PHARMACEUTICALS USA INC (US) | 2014-11-06 | — | — | US | disclosed |
| US-8586762-B2 | Process for producing fused imidazole compound, reformatsky reagent in stable form, and process for producing the same | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-11-19 | — | — | US | disclosed |
| EP-2613780-A1 | METHODS FOR CONCOMITANT TREATMENT OF THEOPHYLLINE AND FEBUXOSTAT | Takeda Pharmaceuticals U.S.A., Inc. (US) | 2013-07-17 | — | — | EP | disclosed |
| US-20130143886-A1 | METHODS FOR PRESERVING AND/OR INCREASING RENAL FUNCTION USING XANTHINE OXIDOREDUCTASE INHIBITORS | TAKEDA PHARMACEUTICALS U.S.A., INC. (US) | 2013-06-06 | — | — | US | disclosed |
| US-5214037-A | Antibiotic, bactericide | SHIONOGI & CO., LTD. (JP) | 1993-05-25 | — | — | US | disclosed |
| EP-0348203-B1 | PHENOLIC THIOETHERS, THEIR PRODUCTION AND USE | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1993-02-24 | — | — | EP | disclosed |
| EP-0521524-A1 | Aminooxypyrrolidinylthiocarbapenem compounds | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1993-01-07 | — | — | EP | disclosed |
| EP-0481116-A1 | A process for producing halomethylcarbapenems | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |
| US-5084214-A | Compounds for the treatment of artheriosclerosis | SHIONOGI & CO., LTD. (JP) | 1992-01-28 | — | — | US | disclosed |
| EP-0467647-A2 | Thioalkylthio cephalosporin derivatives | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1992-01-22 | — | — | EP | disclosed |
| US-5064954-A | Phosphorylation of hydroxymethylcarbapem and halogenation; bactericides | SHIONOGI & CO., LTD. (JP) | 1991-11-12 | — | — | US | disclosed |
| EP-0415566-A1 | Heterocyclic compounds, processes for producing them and pharmaceutical compositions comprising them | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1991-03-06 | — | — | EP | disclosed |
| EP-0348203-A1 | Phenolic thioethers, their production and use | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1989-12-27 | — | — | EP | disclosed |
| US-4731362-A | Alkylcarbamoyloxymethylcephem compounds | SHIONOGI & CO., LTD. (JP) | 1988-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160317505-A1 | NOVEL MODIFIED RELEASE DOSAGE FORMS OF XANTHINE OXIDOREDUCTASE INHIBITOR OR XANTHINE OXIDASE INHIBITORS | XDH, PNPO, DUOX1 | MAPT 3338/4885MAPK1 4009/4885KMT2A 3734/4885 |
| US-20140329868-A1 | METHODS FOR TREATING HYPERTENSION | XDH, REN, CYP11B2 | MAPT 3785/4885MAPK1 2553/4885KMT2A 2181/4885 |
| US-20130143886-A1 | METHODS FOR PRESERVING AND/OR INCREASING RENAL FUNCTION USING XANTHINE OXIDOREDUCTASE INHIBITORS | XDH, GLS, REN | MAPT 4025/4885MAPK1 2287/4885KMT2A 2973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.