Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 9/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | GPX4 | P36969 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 4/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131179 | 0.90 | F2 (0.42) | F7MAPTKDM4EALDH1A1APAF1 | |
| SCHEMBL3128380 | 0.86 | KDM4E (0.50) | F7MAPTKDM4EALDH1A1APAF1 | |
| SCHEMBL3207727 | 0.86 | CYP2C19 (0.39) | CYP2C19CYP2C9KCNH2MAPTGPX4 | |
| SCHEMBL3121001 | 0.85 | GPX4 (0.44) | CYP2C19CYP2C9KCNH2MAPTKDM4E | |
| SCHEMBL3126018 | 0.84 | DHFR (0.48) | MAPTKDM4EALDH1A1APAF1GPX4 | |
| SCHEMBL3118114 | 0.79 | CYP3A4 (0.39) | CYP2C19CYP2C9GPX4TDP1 | |
| SCHEMBL3123550 | 0.76 | F2 (0.42) | F7CYP2C19CYP2C9MAPTKDM4E | |
| SCHEMBL3126185 | 0.75 | BRD4 (0.48) | F7CYP2C19CYP2C9KCNH2MAPT | |
| SCHEMBL3129552 | 0.75 | GPX4 (0.43) | CYP2C19CYP2C9MAPTKDM4EALDH1A1 | |
| SCHEMBL3118081 | 0.72 | PDE4B (0.41) | MAPTKDM4EALDH1A1GPX4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-02-04 | — | — | US | disclosed |
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE3B | F7 3964/4885CYP2C19 241/4885CYP2C9 310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.