Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPX4 | P36969 | 12/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3118114 | 0.92 | CYP3A4 (0.39) | GPX4PDE4BLMNASMN1; SMN2AAK1 | |
| SCHEMBL3207727 | 0.89 | CYP2C19 (0.39) | GPX4MAPTMEN1KMT2APDE4B | |
| SCHEMBL3121001 | 0.89 | GPX4 (0.44) | GPX4MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3128380 | 0.82 | KDM4E (0.50) | GPX4MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3126018 | 0.80 | DHFR (0.48) | GPX4MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3120371 | 0.80 | AAK1 (0.41) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3118081 | 0.78 | PDE4B (0.41) | GPX4MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3129215 | 0.77 | L3MBTL1 (0.56) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL3131820 | 0.77 | GRM4 (0.44) | GPX4MAPTMEN1KMT2AKDM4E | |
| SCHEMBL2908810 | 0.76 | EGFR (0.45) | GPX4MAPTKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |