Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3117583 | 0.93 | MAPT (0.44) | AAK1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3121033 | 0.93 | ALDH1A1 (0.42) | AAK1ALDH1A1S1PR1MEN1KMT2A | |
| SCHEMBL3126180 | 0.91 | AAK1 (0.39) | AAK1ALDH1A1LMNAS1PR1MEN1 | |
| SCHEMBL3130706 | 0.90 | AAK1 (0.39) | AAK1LMNAMEN1KMT2AKDM4E | |
| SCHEMBL3121098 | 0.89 | AAK1 (0.40) | AAK1ALDH1A1LMNAS1PR1MEN1 | |
| SCHEMBL3117907 | 0.78 | ALDH1A1 (0.41) | ALDH1A1LMNAS1PR1MEN1KMT2A | |
| SCHEMBL3132672 | 0.78 | PDE4B (0.45) | AAK1L3MBTL1 | |
| SCHEMBL3131223 | 0.76 | L3MBTL1 (0.40) | AAK1ALDH1A1KMT2AHPGDNPSR1 | |
| SCHEMBL3131836 | 0.76 | PDE4A (0.45) | — | |
| SCHEMBL3121296 | 0.75 | L3MBTL1 (0.39) | AAK1LMNAMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |