SCHEMBL31293746

SCHEMBL31293746

CCOC(=O)c1cnn2ccn(C3COC3)c12

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.42
KDM4E B2RXH2 5/20 0.38
RAB9A P51151 3/20 0.38
NPC1 O15118 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
ALDH1A1 P00352 7/20 0.38
HPGD P15428 4/20 0.38
TSHR P16473 2/20 0.37
KMT2A Q03164 2/20 0.37
MEN1 O00255 1/20 0.37
HSD17B10 Q99714 4/20 0.37
PDE4B Q07343 1/20 0.36
DRD2 P14416 1/20 0.36
DRD4 P21917 1/20 0.36
DRD3 P35462 1/20 0.36
HIF1A Q16665 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8977924 0.76 RAB9A (0.45) LMNAKDM4ERAB9ANPC1SMN1; SMN2
SCHEMBL25338063 0.74 TGFBR1 (0.42) LMNAKDM4ERAB9ANPC1SMN1; SMN2
SCHEMBL21997936 0.74 TGFBR1 (0.44) LMNAKDM4ERAB9ANPC1SMN1; SMN2
SCHEMBL23289755 0.73 LMNA (0.44) LMNAKDM4ERAB9ANPC1SMN1; SMN2
SCHEMBL30554017 0.70 ADORA2B (0.41) LMNAKDM4EALDH1A1HPGDHSD17B10
SCHEMBL12803550 0.68 OGA (0.48) LMNARAB9ASMN1; SMN2ALDH1A1TSHR
SCHEMBL21997232 0.67 KDM4E (0.53) KDM4ERAB9ANPC1SMN1; SMN2ALDH1A1
SCHEMBL16718858 0.66 HSD17B10 (0.67) LMNAKDM4ERAB9ANPC1SMN1; SMN2
SCHEMBL10204204 0.66 PDE2A (0.53) KDM4ERAB9ANPC1SMN1; SMN2ALDH1A1
SCHEMBL25191124 0.66 TGFBR1 (0.47) LMNAKDM4ERAB9ANPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4724439-A1 HETEROARYL DERIVATIVES AS DDRS INHIBITORS Chiesi Farmaceutici S.p.A. (IT) 2026-04-15 EP disclosed
WO-2024251855-A1 HETEROARYL DERIVATIVES AS DDRS INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2024-12-12 WO disclosed