Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 5/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | CIT | O14578 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3118114 | 0.94 | CYP3A4 (0.39) | CYP2C19CYP2C9CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL3129552 | 0.89 | GPX4 (0.43) | CYP2C19CYP2C9CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL3121001 | 0.88 | GPX4 (0.44) | CYP2C19CYP2C9KCNH2CYP1A2AAK1 | |
| SCHEMBL3129490 | 0.86 | F7 (0.41) | CYP2C19CYP2C9KCNH2GPX4MEN1 | |
| SCHEMBL3129223 | 0.81 | PDE4B (0.40) | CYP2C19CYP2C9CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL3132091 | 0.80 | AAK1 (0.42) | CYP2C19CYP2C9KCNH2CYP3A4CYP1A2 | |
| SCHEMBL3132090 | 0.78 | GAA (0.39) | CYP2C19CYP2C9KCNH2CYP3A4CYP1A2 | |
| SCHEMBL3131179 | 0.75 | F2 (0.42) | NPC1RAB9ASMN1; SMN2GPX4S1PR1 | |
| SCHEMBL3128380 | 0.72 | KDM4E (0.50) | SMN1; SMN2GPX4S1PR1MEN1MAPT | |
| SCHEMBL3126018 | 0.72 | DHFR (0.48) | NPC1SMN1; SMN2GPX4MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE3B | CYP2C19 241/4885CYP2C9 310/4885KCNH2 1582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.