Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.46 |
| ▸ | RAB9A | P51151 | 9/20 | 0.46 |
| ▸ | HPGD | P15428 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | CASP3 | P42574 | 4/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | AGPAT2 | O15120 | 5/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.41 |
| ▸ | TP53 | P04637 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131839 | 1.00 | KDM4E (0.46) | KDM4ERAB9AHPGDSMN1; SMN2NPC1 | |
| SCHEMBL3137253 | 0.88 | RAB9A (0.46) | KDM4ERAB9AHPGDSMN1; SMN2NPC1 | |
| SCHEMBL3137262 | 0.88 | RAB9A (0.46) | KDM4ERAB9AHPGDSMN1; SMN2NPC1 | |
| SCHEMBL3137503 | 0.88 | NPC1 (0.38) | KDM4ERAB9ASMN1; SMN2NPC1AGPAT2 | |
| SCHEMBL3137492 | 0.88 | NPC1 (0.38) | KDM4ERAB9ASMN1; SMN2NPC1AGPAT2 | |
| SCHEMBL3138005 | 0.83 | HPGD (0.50) | KDM4ERAB9AHPGDSMN1; SMN2NPC1 | |
| SCHEMBL3130864 | 0.78 | PTGES (0.48) | KDM4ERAB9AHPGDSMN1; SMN2NPC1 | |
| SCHEMBL3130870 | 0.78 | PTGES (0.48) | KDM4ERAB9AHPGDSMN1; SMN2NPC1 | |
| SCHEMBL4519927 | 0.77 | AGPAT2 (0.63) | KDM4ERAB9AHPGDSMN1; SMN2NPC1 | |
| SCHEMBL3131870 | 0.76 | PTGES (0.69) | KDM4ERAB9AHPGDNPC1AGPAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004301-A1 | Benzoxazoles Useful in the Treatment of Inflammation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-07 | — | — | US | disclosed |
| EP-2102177-A1 | BENZOXAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Boehringer Ingelheim International GmbH (DE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008071944-A1 | BENZOXAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004301-A1 | Benzoxazoles Useful in the Treatment of Inflammation | IL4I1, EPX, IL4 | KDM4E 1264/4885RAB9A 3680/4885HPGD 411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.