Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.38 |
| ▸ | CDK4 | P11802 | 5/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 3/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22822703 | 0.97 | AURKA (0.36) | AURKACDK4CDK1INSRPDGFRB | |
| SCHEMBL29547910 | 0.81 | DGAT1 (0.33) | AURKACDK4 | |
| SCHEMBL21810407 | 0.81 | DGAT1 (0.33) | AURKACDK4 | |
| SCHEMBL22801997 | 0.79 | HTR6 (0.36) | AURKACDK4CDK1INSRPDGFRB | |
| SCHEMBL8513406 | 0.76 | MTNR1A (0.40) | AURKACDK4CDK1INSRPDGFRB | |
| SCHEMBL22802002 | 0.74 | KDM5A (0.34) | AURKASRC | |
| SCHEMBL22802031 | 0.74 | KDM5A (0.34) | AURKASRC | |
| SCHEMBL22801941 | 0.73 | HCAR1 (0.45) | — | |
| SCHEMBL28961559 | 0.72 | DGAT1 (0.41) | AURKACDK4CDK1INSRPDGFRB | |
| SCHEMBL31749158 | 0.71 | CYP11B2 (0.36) | AURKACDK4CDK1INSRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4735420-A1 | ARYL INDOL-3-YL KETONE AND ARYL INDAZOL-3-YL KETONE INHIBITORS OF KIF18A | Volastra Therapeutics, Inc. (US) | 2026-05-06 | — | — | EP | disclosed |
| WO-2025007055-A1 | ARYL INDOL-3-YL KETONE AND ARYL INDAZOL-3-YL KETONE INHIBITORS OF KIF18A | VOLASTRA THERAPEUTICS, INC. (US) | 2025-01-02 | — | — | WO | disclosed |