SCHEMBL31334208

SCHEMBL31334208

CC(C)(C)OC(=O)C[C@H]1CC[C@H](CN2CCN(c3ccc(NC4CCC(=O)NC4=O)cc3F)CC2)CC1

nearest known ligand 0.49

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 17/20 0.49
DDB1 Q16531 16/20 0.49
HDAC8 Q9BY41 1/20 0.38
DRD2 P14416 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334803 0.95 CRBN (0.47) CRBNDDB1HDAC8
SCHEMBL24126005 0.92 CRBN (0.51) CRBNDDB1
SCHEMBL31334549 0.91 CRBN (0.48) CRBNDDB1HDAC8
SCHEMBL31333780 0.91 CRBN (0.49) CRBNDDB1
SCHEMBL31334959 0.89 DRD2 (0.51) CRBNDDB1HDAC8DRD2
SCHEMBL27225240 0.89 DRD2 (0.51) CRBNDDB1DRD2
SCHEMBL27162923 0.89 DDB1 (0.59) CRBNDDB1
SCHEMBL31701449 0.89 DDB1 (0.59) CRBNDDB1
SCHEMBL31334602 0.88 CRBN (0.47) CRBNDDB1
SCHEMBL30120484 0.88 CRBN (0.53) CRBNDDB1HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed