SCHEMBL31345967

SCHEMBL31345967

NS(=O)(=O)c1cccc(C2Cc3cc(C(F)(F)F)cc(Cl)c3O2)c1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA2 P00918 8/20 0.37
CA1 P00915 6/20 0.37
CA9 Q16790 5/20 0.37
CA12 O43570 3/20 0.37
ALDH1A1 P00352 3/20 0.36
LMNA P02545 2/20 0.36
KDM4E B2RXH2 1/20 0.36
CA7 P43166 1/20 0.36
SLC9A3 P48764 1/20 0.36
MAPT P10636 1/20 0.33
HTT P42858 1/20 0.33
PNMT P11086 1/20 0.33
NR1H2 P55055 2/20 0.33
NR1H3 Q13133 2/20 0.33
CA13 Q8N1Q1 1/20 0.32
KIF11 P52732 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31345956 0.90 LMNA (0.34) CA2CA1ALDH1A1LMNAMAPT
SCHEMBL31346119 0.89 MRGPRX4 (0.42) CA2CA1ALDH1A1LMNAMAPT
SCHEMBL31346120 0.83 CA2 (0.38) CA2CA1CA9CA12LMNA
SCHEMBL31346121 0.81 CA2 (0.41) CA2CA1CA9CA12CA7
SCHEMBL31345985 0.81 TEAD1 (0.37)
SCHEMBL31346090 0.79 ALDH1A1 (0.43) ALDH1A1
SCHEMBL31346162 0.78 CYP19A1 (0.45)
SCHEMBL31346110 0.78 CYP19A1 (0.45)
SCHEMBL31346097 0.77 PARP1 (0.33) MAPT
SCHEMBL31346140 0.72 PKM (0.36) CA2CA1NR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4712967-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST Enveda Therapeutics, Inc. (US) 2026-03-25 EP disclosed
WO-2024239000-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST ENVEDA THERAPEUTICS, INC. (US) 2024-11-21 WO disclosed