SCHEMBL3134637

SCHEMBL3134637

O=C1/C(=C/c2ccccc2)Sc2ccccc21

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 15/20 0.69
MEN1 O00255 12/20 0.69
KMT2A Q03164 12/20 0.69
POLB P06746 4/20 0.62
SMN1; SMN2 Q16637 5/20 0.61
MAPK1 P28482 3/20 0.61
CASP3 P42574 2/20 0.61
SENP8 Q96LD8 2/20 0.61
SENP7 Q9BQF6 2/20 0.61
SENP6 Q9GZR1 2/20 0.61
RAB9A P51151 2/20 0.61
NPC1 O15118 2/20 0.59
CYP1A2 P05177 3/20 0.58
CYP2C19 P33261 3/20 0.58
CYP3A4 P08684 2/20 0.58
CYP2C9 P11712 2/20 0.58
HCRTR1 O43613 1/20 0.58
CYP2D6 P10635 1/20 0.58
NFKB1 P19838 1/20 0.58
NFKB2 Q00653 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3134644 1.00 MAPT (0.69) MAPTMEN1KMT2APOLBSMN1; SMN2
SCHEMBL12692508 0.86 MAPT (0.64) MAPTMEN1KMT2APOLBSMN1; SMN2
SCHEMBL12692428 0.86 TYR (0.65) MAPTMEN1KMT2APOLBSMN1; SMN2
SCHEMBL14139632 0.86 MAPT (0.60) MAPTMEN1KMT2APOLBSMN1; SMN2
SCHEMBL12204420 0.86 MAPT (0.60) MAPTMEN1KMT2APOLBSMN1; SMN2
SCHEMBL7876191 0.86 MAPT (0.64) MAPTMEN1KMT2APOLBSMN1; SMN2
SCHEMBL7876190 0.86 MAPT (0.64) MAPTMEN1KMT2APOLBSMN1; SMN2
SCHEMBL14099557 0.82 MAPT (0.60) MAPTMEN1KMT2APOLBSMN1; SMN2
SCHEMBL22624898 0.82 MAPT (0.59) MAPTMEN1KMT2APOLBSMN1; SMN2
SCHEMBL10118327 0.82 MAPT (1.00) MAPTMEN1KMT2APOLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1484051-B1 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. OREAL (FR) 2013-08-21 EP claimed
US-20090074820-A1 AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF L'OREAL (FR) 2009-03-19 US claimed
US-7166274-B2 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds L'OREAL (FR) 2007-01-23 US claimed
US-20050008588-A1 Aminoarylvinyl-s-triazine compounds and uses thereof L'OREAL (FR) 2005-01-13 US claimed
EP-1484051-A2 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. L'OREAL (FR) 2004-12-08 EP claimed
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SOCIETE L'OREAL S.A. (FR) 2004-03-11 US claimed
EP-1370232-A2 COSMETIC SOLAR PROTECTION COMPOSITIONS BASED ON A SYNERGIC MIXTURE OF FILTERS AND USES L'OREAL (FR) 2003-12-17 EP claimed
US-6627180-B2 Particles having protection factor UV-APPD and an amino substituted 2-hydroxybenzophenone SOCIETE L'OREAL S.A. (FR) 2003-09-30 US claimed
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS SOCIETE L'OREAL S.A. (FR) 2003-08-14 US claimed
EP-1317918-A1 Cosmetic sunscreen compositions based on synergistic filter mixture and their use L'OREAL (FR) 2003-06-11 EP claimed
WO-2002056858-A1 SOLAR PROTECTION COMPOSITIONS L'OREAL (FR) 2002-07-25 WO claimed
WO-2002049597-A2 COSMETIC SOLAR PROTECTION COMPOSITIONS BASED ON A SYNERGIC MIXTURE OF FILTERS AND USES L'OREAL (FR) 2002-06-27 WO claimed
EP-3709966-B1 COMPOSITIONS COMPRISING AT LEAST ONE ACRYLIC POLYMER AND AT LEAST ONE INSOLUBLE ORGANIC SCREENING AGENT OREAL (FR) 2024-12-11 EP disclosed
US-20230288299-A1 ELECTRON MICROSCOPY GRIDS AND HIGH-RESOLUTION STRUCTURAL DETERMINATION METHODS UNIVERSITEIT GENT (BE) 2023-09-14 US disclosed
US-20220143183-A1 PHOTOSWITCHABLE PROTACS AND SYNTHESIS AND USES THEREOF NEW YORK UNIVERSITY 2022-05-12 US disclosed
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER L'OREAL (FR) 2021-11-11 US disclosed
US-20030053966-A1 Insoluble organic UV screening agents of aryl vinylene ketone type, and cosmetic use thereof L'OREAL (FR) 2003-03-20 US disclosed
EP-1281391-A1 Organic insoluble UV filters of the aryl vinylene ketone type and their use in cosmetics L'OREAL (FR) 2003-02-05 EP disclosed
WO-2002056858-A1 SOLAR PROTECTION COMPOSITIONS L'OREAL (FR) 2002-07-25 WO disclosed
WO-2002049597-A2 COSMETIC SOLAR PROTECTION COMPOSITIONS BASED ON A SYNERGIC MIXTURE OF FILTERS AND USES L'OREAL (FR) 2002-06-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050008588-A1 Aminoarylvinyl-s-triazine compounds and uses thereof TYR, AAAS, ALAD MAPT 910/4885MEN1 3700/4885KMT2A 1215/4885
US-20220143183-A1 PHOTOSWITCHABLE PROTACS AND SYNTHESIS AND USES THEREOF MDM2, UBE3C, CUL1 MAPT 1788/4885MEN1 1217/4885KMT2A 777/4885
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SUCLG1, CUTA, DLD MAPT 2067/4885MEN1 4027/4885KMT2A 3376/4885
US-20030053966-A1 Insoluble organic UV screening agents of aryl vinylene ketone type, and cosmetic use thereof PRKDC, AHR, TYR MAPT 727/4885MEN1 4562/4885KMT2A 1006/4885
US-20090074820-A1 AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF TYR, AAAS, ALAD MAPT 874/4885MEN1 3854/4885KMT2A 1027/4885
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER ERCC5, CUTA, PLIN5 MAPT 2849/4885MEN1 2561/4885KMT2A 3476/4885
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS HADHB, SDHA, ERCC4 MAPT 922/4885MEN1 3716/4885KMT2A 3626/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.