Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | CBFB | Q13951 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 6/20 | 0.34 |
| ▸ | CNR2 | P34972 | 5/20 | 0.34 |
| ▸ | REN | P00797 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2810509 | 0.89 | CBFB (0.41) | DAOCBFBCYP4F2CYP4A11CYP2D6 | |
| SCHEMBL8263863 | 0.84 | ALDH1A1 (0.41) | DAOCBFBCNR1CNR2MAPT | |
| SCHEMBL2807883 | 0.82 | ACHE (0.48) | CBFBCNR1CNR2 | |
| SCHEMBL11956987 | 0.81 | HTR1A (0.40) | CBFBCYP4F2CYP4A11MAPT | |
| SCHEMBL18860620 | 0.81 | MAPT (0.43) | CBFBCYP4F2CYP4A11CYP2D6MAPT | |
| SCHEMBL16397054 | 0.78 | PLAU (0.36) | DAOENPP2RENKCNH2MAPT | |
| SCHEMBL16092470 | 0.76 | ACHE (0.40) | CNR1CNR2CYP4F2CYP4A11 | |
| SCHEMBL10068777 | 0.76 | MAPT (0.50) | CYP4F2CYP4A11MAPT | |
| SCHEMBL3129803 | 0.76 | MAPT (0.50) | CYP4F2CYP4A11MAPT | |
| SCHEMBL2810985 | 0.76 | PDE4A (0.40) | CNR1CNR2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076359-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-12-13 | — | — | US | disclosed |
| EP-2097377-B1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2010-07-07 | — | — | EP | disclosed |
| US-20100063091-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2010-03-11 | — | — | US | disclosed |
| EP-2097377-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008058387-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063091-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | DAO 1748/4885CBFB 3930/4885ENPP2 1744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.