Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carbimazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPO | P22079 | 9/20 | 0.96 |
| ▸ | LMNA | P02545 | 1/20 | 0.96 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.96 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbimazole SCHEMBL44211 | 0.98 | LPO (1.00) | LPOLMNACYP1A2BCHEALDH1A1 | |
| Carbimazole SCHEMBL28078672 | 0.96 | LPO (0.96) | LPOLMNACYP1A2BCHEALDH1A1 | |
| Carbimazole SCHEMBL28086764 | 0.85 | LPO (0.75) | LPOLMNACYP1A2BCHEALDH1A1 | |
| Carbimazole SCHEMBL20771744 | 0.80 | LPO (0.66) | LPOLMNACYP1A2ALDH1A1TSHR | |
| SCHEMBL26295022 | 0.71 | LPO (0.57) | LPOLMNACYP1A2BCHEALDH1A1 | |
| SCHEMBL7548705 | 0.66 | LPO (0.50) | LPOLMNACYP1A2BCHEALDH1A1 | |
| SCHEMBL15284133 | 0.66 | LPO (0.50) | LPOLMNACYP1A2BCHEALDH1A1 | |
| SCHEMBL29117082 | 0.64 | LPO (0.49) | LPOLMNACYP1A2BCHEALDH1A1 | |
| SCHEMBL13278237 | 0.64 | LPO (0.49) | LPOLMNACYP1A2BCHEALDH1A1 | |
| SCHEMBL163149 | 0.63 | LPO (0.47) | LPOLMNACYP1A2BCHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203192-A1 | WOUND CARE FORMULATION | Northern Health And Social Care Trust (GB) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009037500-A1 | WOUND CARE FORMULATION | NORTHERN HEALTH AND SOCIAL CARE TRUST (GB) | 2009-03-26 | — | — | WO | disclosed |