Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carbimazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPO | P22079 | 6/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | CTSG | P08311 | 1/20 | 0.32 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbimazole SCHEMBL44211 | 0.81 | LPO (1.00) | LPOLMNACYP1A2ALDH1A1TSHR | |
| Carbimazole SCHEMBL28078672 | 0.80 | LPO (0.96) | LPOLMNACYP1A2ALDH1A1MAPT | |
| Carbimazole SCHEMBL3137059 | 0.80 | LPO (0.96) | LPOLMNACYP1A2ALDH1A1MAPT | |
| Carbimazole SCHEMBL28086764 | 0.70 | LPO (0.75) | LPOLMNACYP1A2ALDH1A1MAPT | |
| SCHEMBL16804134 | 0.66 | LMNA (0.44) | LMNAALDH1A1MAPTELANEKCNH2 | |
| Paramethadione SCHEMBL23832172 | 0.63 | LMNA (0.70) | LMNAELANECTSGPRTN3 | |
| Trimethadione SCHEMBL13724328 | 0.62 | LMNA (0.83) | LMNAELANECTSGPRTN3 | |
| SCHEMBL26295022 | 0.59 | LPO (0.57) | LPOLMNACYP1A2ALDH1A1MAPT | |
| SCHEMBL15284133 | 0.57 | LPO (0.50) | LPOLMNACYP1A2ALDH1A1MAPT | |
| SCHEMBL7548705 | 0.57 | LPO (0.50) | LPOLMNACYP1A2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046303-A1 | A METHOD FOR PREDICTING A SUBJECT'S RESPONSE TO SLC MODULATOR THERAPY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-03-07 | — | — | WO | disclosed |