Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carbimazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPO | P22079 | 10/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbimazole SCHEMBL44211 | 0.87 | LPO (1.00) | LPOLMNACYP1A2ALDH1A1GAA | |
| Carbimazole SCHEMBL3137059 | 0.85 | LPO (0.96) | LPOLMNACYP1A2ALDH1A1KDM4E | |
| Carbimazole SCHEMBL28078672 | 0.85 | LPO (0.96) | LPOLMNACYP1A2ALDH1A1KDM4E | |
| SCHEMBL26295022 | 0.82 | LPO (0.57) | LPOLMNACYP1A2ALDH1A1KMT2A | |
| SCHEMBL15284133 | 0.71 | LPO (0.50) | LPOLMNACYP1A2ALDH1A1KMT2A | |
| Carbimazole SCHEMBL20771744 | 0.70 | LPO (0.66) | LPOLMNACYP1A2ALDH1A1MAPT | |
| SCHEMBL7548705 | 0.64 | LPO (0.50) | LPOLMNACYP1A2ALDH1A1KMT2A | |
| SCHEMBL7548711 | 0.63 | NUDT1 (0.38) | LPOLMNACYP1A2ALDH1A1KMT2A | |
| SCHEMBL31452743 | 0.58 | LPO (0.46) | LPOLMNACYP1A2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8710113 | 0.57 | LPO (0.45) | LPOLMNACYP1A2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |