Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carbimazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPO | P22079 | 9/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.34 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbimazole SCHEMBL3137059 | 0.98 | LPO (0.96) | LPOLMNACYP1A2BCHEALDH1A1 | |
| Carbimazole SCHEMBL28078672 | 0.98 | LPO (0.96) | LPOLMNACYP1A2BCHEALDH1A1 | |
| Carbimazole SCHEMBL28086764 | 0.87 | LPO (0.75) | LPOLMNACYP1A2BCHEALDH1A1 | |
| Carbimazole SCHEMBL20771744 | 0.81 | LPO (0.66) | LPOLMNACYP1A2ALDH1A1TSHR | |
| SCHEMBL26295022 | 0.73 | LPO (0.57) | LPOLMNACYP1A2BCHEALDH1A1 | |
| SCHEMBL7548705 | 0.67 | LPO (0.50) | LPOLMNACYP1A2BCHEALDH1A1 | |
| SCHEMBL15284133 | 0.67 | LPO (0.50) | LPOLMNACYP1A2BCHEALDH1A1 | |
| SCHEMBL13278237 | 0.65 | LPO (0.49) | LPOLMNACYP1A2BCHEALDH1A1 | |
| SCHEMBL29117082 | 0.65 | LPO (0.49) | LPOLMNACYP1A2BCHEALDH1A1 | |
| SCHEMBL163149 | 0.64 | LPO (0.47) | LPOLMNACYP1A2BCHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4040 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724042-A1 | METHOD FOR IMPROVING THE INGESTION OF A LIQUID OR VISCOUS SUBSTANCE | Ceva Santé Animale (FR) | 2026-04-15 | — | — | EP | claimed |
| US-20250248940-A1 | Biopolymer Formulations for Drug Delivery | 11584022 CANADA INC. (CA) | 2025-08-07 | — | — | US | claimed |
| WO-2025093717-A1 | METHODS OF IMPROVING ANTI-FCRN THERAPIES | IMMUNOVANT SCIENCES GMBH (CH) | 2025-05-08 | — | — | WO | claimed |
| EP-4547280-A1 | BIOPOLYMER FORMULATIONS FOR DRUG DELIVERY | 11584022 Canada Inc. (CA) | 2025-05-07 | — | — | EP | claimed |
| CN-119789873-A | Biopolymer formulation for drug delivery | 11584022加拿大有限公司 | 2025-04-08 | — | — | CN | claimed |
| CN-119757557-A | Detection method of whitening component | 上海市食品药品检验研究院 | 2025-04-04 | — | — | CN | claimed |
| WO-2024189607-A1 | METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR DISEASES TREATMENT | DIDENKO KIRILL (MX) | 2024-09-19 | — | — | WO | claimed |
| EP-4427233-A1 | METHOD, SYSTEM AND COMPUTER PROGRAM FOR COMPUTATION OF OPTIMAL INDIVIDUAL DOSING REGIMEN, PARTICULARLY SUBJECT TO CLINICAL CONSTRAINTS | Universität Basel (CH) | 2024-09-11 | — | — | EP | claimed |
| US-20240282424-A1 | METHOD, SYSTEM AND COMPUTER PROGRAM FOR COMPUTATION OF OPTIMAL INDIVIDUAL DOSING REGIMEN, PARTICULARLY SUBJECT TO CLINICAL CONSTRAINTS | Universität Konstanz (DE) | 2024-08-22 | — | — | US | claimed |
| US-20240216409-A1 | Patient Treatment Via Teratogenic Pharmaceutical Compounds | NANT HOLDINGS IP, LLC (US) | 2024-07-04 | — | — | US | claimed |
| WO-1994012183-A1 | USE OF THIOURELEYLENES AND THIABENDAZOLE IN AUTOIMMUNE DISEASES | ELIAS ALAN N (US) | 1994-06-09 | — | — | WO | claimed |
| US-5310742-A | Uses for thioureylenes | ELIAS ALAN N (US) | 1994-05-10 | — | — | US | claimed |
| CN-1085079-A | Antithyroid cream for external application | CHEN LING (CN) | 1994-04-13 | — | — | CN | claimed |
| CN-1084078-A | Antithyroid cream for external application | CHEN LING (CN) | 1994-03-23 | — | — | CN | claimed |
| EP-0434470-B1 | Protection against chemically-induced kidney damage by methimazole | WISCONSIN ALUMNI RES FOUND (US) | 1994-03-02 | — | — | EP | claimed |
| CN-1079896-A | The compositions of topical aromatic releasing | RICHARDSON VICKS INC (US) | 1993-12-29 | — | — | CN | claimed |
| US-5087441-A | Protection against chemically-induced kidney damage by methimazole | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1992-02-11 | — | — | US | claimed |
| EP-0434470-A2 | Protection against chemically-induced kidney damage by methimazole | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1991-06-26 | — | — | EP | claimed |
| US-5010092-A | Protection against chemically-induced kidney damage by methimazole | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1991-04-23 | — | — | US | claimed |
| US-4690824-A | Solid pharmaceutical formulations for slow, zero order release via controlled surface erosion: expanded range | REDI-ROWELL, INC. (US) | 1987-09-01 | — | — | US | claimed |