SCHEMBL313724

SCHEMBL313724

C#Cc1c(C)cc(F)c(F)c1F

nearest known ligand 0.31

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26377802 0.82 RAPGEF4 (0.31) RAPGEF4
SCHEMBL15538568 0.82
SCHEMBL4436602 0.77 TRPV4 (0.41)
SCHEMBL313725 0.73
SCHEMBL15244477 0.72 CA1 (0.33)
SCHEMBL30567470 0.69 RAPGEF4 (0.38) RAPGEF4
SCHEMBL823681 0.69 RAPGEF4 (0.38) RAPGEF4
SCHEMBL14435896 0.69 SELL (0.32) RAPGEF4
SCHEMBL25873827 0.68 ACHE (0.32)
SCHEMBL24744660 0.68 TRPV4 (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107840796-B Preparation method of trifluoromethyl alkenyl ester 西安近代化学研究所 2020-12-15 CN disclosed
US-8093177-B2 Metal oxides having molecular and/or biomolecular functionalization WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2012-01-10 US disclosed
WO-2010053847-A2 MOLECULAR AND BIOMOLECULAR FUNCTIONALIZATION OF METAL OXIDES WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2010-05-14 WO disclosed
US-20100108490-A1 MOLECULAR AND BIOMOLECULAR FUNCTIONALIZATION OF METAL OXIDES WISCONSIN ALUMNI RESEARCH FOUNDATION 2010-05-06 US disclosed