SCHEMBL31373349

SCHEMBL31373349

CCCCSc1c(/C=C(\C#N)c2nc3ccc(C(=O)O)cc3s2)c(=O)oc2cc(N(CC)CC)c([N+](=O)[O-])cc12

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HCAR3 P49019 3/20 0.37
▸ MEN1 O00255 5/20 0.35
▸ MAPT P10636 5/20 0.35
▸ KMT2A Q03164 5/20 0.35
▸ POLB P06746 4/20 0.35
▸ ALDH1A1 P00352 4/20 0.35
▸ HTT P42858 2/20 0.35
▸ MAPK1 P28482 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ RECQL P46063 3/20 0.35
▸ TDP1 Q9NUW8 2/20 0.35
▸ BLM P54132 2/20 0.35
▸ MCL1 Q07820 2/20 0.35
▸ THRB P10828 1/20 0.35
▸ SAE1 Q9UBE0 2/20 0.34
▸ UBA2 Q9UBT2 2/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ APEX1 P27695 1/20 0.34
▸ DNMT1 P26358 2/20 0.31
▸ LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28946490 0.91 MEN1 (0.45) MEN1MAPTKMT2APOLBALDH1A1
SCHEMBL30076449 0.91 MEN1 (0.45) MEN1MAPTKMT2APOLBALDH1A1
SCHEMBL28946489 0.88 HCAR3 (0.40) HCAR3MEN1MAPTKMT2APOLB
SCHEMBL30076468 0.88 HCAR3 (0.40) HCAR3MEN1MAPTKMT2APOLB
SCHEMBL28946495 0.81 MAPT (0.34) HCAR3MAPTALDH1A1MAPK1KDM4E
SCHEMBL30827138 0.81 SLC16A3 (0.34) HCAR3MEN1MAPTKMT2APOLB
SCHEMBL28927435 0.81 SLC16A3 (0.34) HCAR3MEN1MAPTKMT2APOLB
SCHEMBL28946484 0.80 EGFR (0.32) HCAR3MEN1MAPTKMT2APOLB
SCHEMBL28946492 0.79 ALDH1A1 (0.35) HCAR3MEN1MAPTKMT2APOLB
SCHEMBL31373352 0.78 HCAR3 (0.37) HCAR3MEN1MAPTKMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260133200-A1 RATIOMETRIC FLUORESCENT PROBE FOR DETECTING A COLORECTAL CANCER MARKER HOMOCYSTEINE WITH HIGH SELECTIVITY AND PREPARATION METHOD THEREFOR HUNAN CANCER HOSPITAL (CN) 2026-05-14 — — US claimed
CN-119462679-A High-selectivity ratio fluorescent probe for detecting homocysteine of colorectal cancer marker, preparation method of high-selectivity ratio fluorescent probe, method for detecting homocysteine by using high-selectivity ratio fluorescent probe and method for imaging homocysteine 湖南省肿瘤医院 2025-02-18 — — CN claimed
US-20260133200-A1 RATIOMETRIC FLUORESCENT PROBE FOR DETECTING A COLORECTAL CANCER MARKER HOMOCYSTEINE WITH HIGH SELECTIVITY AND PREPARATION METHOD THEREFOR HUNAN CANCER HOSPITAL (CN) 2026-05-14 — — US disclosed
CN-119462679-A High-selectivity ratio fluorescent probe for detecting homocysteine of colorectal cancer marker, preparation method of high-selectivity ratio fluorescent probe, method for detecting homocysteine by using high-selectivity ratio fluorescent probe and method for imaging homocysteine 湖南省肿瘤医院 2025-02-18 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260133200-A1 RATIOMETRIC FLUORESCENT PROBE FOR DETECTING A COLORECTAL CANCER MARKER HOMOCYSTEINE WITH HIGH SELECTIVITY AND PREPARATION METHOD THEREFOR MTHFD1, DHFR, MTHFD2 HCAR3 97/4885MEN1 1236/4885MAPT 4440/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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