Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 6/20 | 0.43 |
| ▸ | THRB | P10828 | 6/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MIF | P14174 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3138766 | 0.86 | PDE2A (0.43) | PTPN7THRATHRBPDE2APDE3B | |
| SCHEMBL3142092 | 0.85 | KDM4E (0.46) | THRATHRBKDM4EHTTKMT2A | |
| SCHEMBL3137369 | 0.83 | THRA (0.56) | THRATHRB | |
| SCHEMBL3146203 | 0.81 | THRA (0.58) | THRATHRBKDM4EKMT2AMEN1 | |
| SCHEMBL5074426 | 0.80 | CYP1A2 (0.44) | THRATHRBKDM4EHTTKMT2A | |
| SCHEMBL5074424 | 0.80 | CYP1A2 (0.44) | THRATHRBKDM4EKMT2AMEN1 | |
| SCHEMBL3128285 | 0.77 | THRB (0.43) | THRATHRB | |
| SCHEMBL3142072 | 0.76 | ALOX15 (0.43) | THRATHRBKDM4EMIFKMT2A | |
| SCHEMBL3138058 | 0.76 | THRA (0.41) | THRATHRBKDM4EMIFKMT2A | |
| SCHEMBL3140925 | 0.76 | THRA (0.45) | PTPN7THRATHRBPDE2APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | TSHR, GHSR, TRHR | PTPN7 757/4885THRA 4/4885THRB 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.