SCHEMBL3138403

SCHEMBL3138403

Nc1ccc(-c2ccc(N)cc2C(=O)c2ccccc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.53
CYP2C8 P10632 2/20 0.53
PBRM1 Q86U86 1/20 0.51
MAPT P10636 3/20 0.49
GAA P10253 1/20 0.49
ALDH1A1 P00352 4/20 0.47
ADORA1 P30542 1/20 0.46
POLB P06746 1/20 0.46
HCRTR1 O43613 1/20 0.45
HCRTR2 O43614 1/20 0.45
TUBB4A P04350 1/20 0.44
TUBB P07437 1/20 0.44
TUBA3C P0DPH7 1/20 0.44
TUBA1B P68363 1/20 0.44
TUBA4A P68366 1/20 0.44
TUBB4B P68371 1/20 0.44
TUBB3 Q13509 1/20 0.44
TUBB2A Q13885 1/20 0.44
TUBB8 Q3ZCM7 1/20 0.44
TUBA3E Q6PEY2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28431907 0.94 CDC25B (0.51) CYP2C9CYP2C8PBRM1MAPTALDH1A1
SCHEMBL3138405 0.93 CYP2C9 (0.53) CYP2C9CYP2C8PBRM1MAPTGAA
SCHEMBL4351040 0.90 CYP2C9 (0.65) CYP2C9CYP2C8PBRM1MAPTGAA
SCHEMBL30341893 0.90 CYP2C9 (0.65) CYP2C9CYP2C8PBRM1MAPTGAA
SCHEMBL30341895 0.87 CYP2C8 (0.57) CYP2C9CYP2C8PBRM1MAPTGAA
SCHEMBL9491730 0.86 MAPT (0.56) CYP2C9CYP2C8PBRM1MAPTGAA
SCHEMBL20854795 0.85 CES2 (0.45) CYP2C9PBRM1MAPTALDH1A1POLB
SCHEMBL28436721 0.84 MAPT (0.49) CYP2C9MAPTGAAALDH1A1TUBB4A
SCHEMBL8748378 0.83 POLB (0.50) CYP2C8PBRM1MAPTALDH1A1POLB
SCHEMBL14744360 0.81 PBRM1 (0.53) CYP2C9CYP2C8PBRM1MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1947515-B1 Electrophotographic photosensitive member, and electrophotgraphic apparatus and process cartridge which make use of the same CANON KK (JP) 2015-09-09 EP disclosed
EP-2184327-B1 Azo pigment, electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KK (JP) 2013-05-15 EP disclosed
US-8309696-B2 AZO pigment, electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2012-11-13 US disclosed
EP-2184327-A2 Azo pigment, electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus Canon Kabushiki Kaisha (JP) 2010-05-12 EP disclosed
US-20100075239-A1 AZO PIGMENT, ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2010-03-25 US disclosed
EP-1542081-B1 Electrophotographic photosensitive member, and electrophotographic apparatus and process cartridge which make use of the same CANON KK (JP) 2009-07-29 EP disclosed
US-7517626-B2 Electrophotographic photosensitive member, and electrophotographic apparatus and process cartridge which make use of the same CANON KABUSHIKI KAISHA (JP) 2009-04-14 US disclosed
EP-1947515-A2 Electrophotographic photosensitive member, and electrophotgraphic apparatus and process cartridge which make use of the same Canon Kabushiki Kaisha (JP) 2008-07-23 EP disclosed
US-7276318-B2 Electrophotographic photosensitive member, and electrophotographic apparatus and process cartridge which make use of the same CANON KABUSHIKI KAISHA (JP) 2007-10-02 US disclosed
US-20070154828-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, AND ELECTROPHOTOGRAPHIC APPARATUS AND PROCESS CARTRIDGE WHICH MAKE USE OF THE SAME CANON KABUSHIKI KAISHA (JP) 2007-07-05 US disclosed
US-20050181292-A1 Electrophotographic photosensitive member, and electrophotographic apparatus and process cartridge which make use of the same CANON KABUSHIKI KAISHA (JP) 2005-08-18 US disclosed
EP-1542081-A1 Electrophotographic photosensitive member, and electrophotographic apparatus and process cartridge which make use of the same CANON KABUSHIKI KAISHA (JP) 2005-06-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100075239-A1 AZO PIGMENT, ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CRY1, IK, APC CYP2C9 101/4885CYP2C8 862/4885PBRM1 111/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.