Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3138557 | 1.00 | AKR1C3 (0.53) | AKR1C3TTRPTP4A1PTPN1PTPN2 | |
| SCHEMBL8746655 | 0.83 | AKR1C3 (0.67) | AKR1C3 | |
| SCHEMBL8746653 | 0.83 | AKR1C3 (0.67) | AKR1C3 | |
| SCHEMBL17041936 | 0.80 | AKR1C3 (0.53) | AKR1C3TTRCYP3A4EGFRCYP2C9 | |
| SCHEMBL8746648 | 0.79 | AKR1C3 (0.57) | AKR1C3KDM4ECYP3A4EGFRLCK | |
| SCHEMBL3418803 | 0.79 | AKR1C3 (0.57) | AKR1C3KDM4ECYP3A4EGFRLCK | |
| SCHEMBL6072489 | 0.76 | PKM (0.57) | AKR1C3KDM4EGAACYP3A4TDP1 | |
| SCHEMBL11303373 | 0.76 | GABBR2 (0.58) | AKR1C3KDM4EGAATSHRCYP3A4 | |
| SCHEMBL11303376 | 0.76 | GABBR2 (0.58) | AKR1C3KDM4EGAATSHRCYP3A4 | |
| SCHEMBL30812355 | 0.76 | PKM (0.57) | AKR1C3KDM4EGAACYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | TSHR, GHSR, TRHR | AKR1C3 262/4885TTR 477/4885PTP4A1 1715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.