Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RARG | P13631 | 2/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895442 | 0.92 | KMO (0.53) | CDC25BTDP1CREBBPSMN1; SMN2KMO | |
| SCHEMBL31401408 | 0.83 | SLC9A1 (0.53) | CDC25BTDP1CREBBPSMN1; SMN2KMO | |
| SCHEMBL30153250 | 0.83 | ALDH1A1 (0.48) | SMN1; SMN2KMT2APKMTSHRSLC6A4 | |
| SCHEMBL22636985 | 0.83 | ALDH1A1 (0.48) | SMN1; SMN2KMT2APKMTSHRSLC6A4 | |
| SCHEMBL31401521 | 0.80 | CREBBP (0.44) | CDC25BTDP1CREBBPSMN1; SMN2KMO | |
| SCHEMBL10148390 | 0.78 | RARG (0.56) | CREBBPKMORARGRARBTSHR | |
| SCHEMBL23045595 | 0.77 | TRPV4 (0.43) | KMT2ATSHR | |
| SCHEMBL665155 | 0.77 | TSHR (0.57) | TDP1CREBBPKMORARGRARB | |
| SCHEMBL1424320 | 0.75 | POLB (0.55) | CDC25BTDP1SMN1; SMN2KMT2APKM | |
| SCHEMBL18283980 | 0.75 | CA12 (0.55) | TDP1CREBBPSMN1; SMN2KMORARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |