Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3140269 | 0.77 | RIPK2 (0.38) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL1339349 | 0.73 | KDM4E (0.36) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL4760890 | 0.73 | HSD11B1 (0.34) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL1338090 | 0.70 | KDM4E (0.52) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL4761086 | 0.69 | EGFR (0.43) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL4762650 | 0.66 | CYP3A4 (0.34) | KDM4EALDH1A1HPGDMEN1CYP1A2 | |
| SCHEMBL3846339 | 0.66 | ALPL (0.49) | KDM4EMAPTMAPK1LMNAKMT2A | |
| SCHEMBL1338134 | 0.66 | CNR1 (0.33) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL29834897 | 0.63 | ALDH1A1 (0.51) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL4762649 | 0.63 | BRD4 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-B1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2010-07-21 | — | — | EP | disclosed |