Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 4/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | RGS12 | O14924 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4762649 | 0.88 | BRD4 (0.34) | WEE1 | |
| SCHEMBL3140269 | 0.75 | RIPK2 (0.38) | HSD11B1ALPLGSK3AGSK3BKDM4E | |
| SCHEMBL3140274 | 0.73 | KDM4E (0.44) | HSD11B1DPP4GSK3AGSK3BKDM4E | |
| SCHEMBL4760378 | 0.73 | HPGD (0.33) | KDM4EALDH1A1HPGDCYP1A2MEN1 | |
| SCHEMBL1339349 | 0.72 | KDM4E (0.36) | HSD11B1ALPLKDM4EALDH1A1HPGD | |
| SCHEMBL3846339 | 0.69 | ALPL (0.49) | ALPLKDM4ELMNAMAPTMAPK1 | |
| SCHEMBL4762650 | 0.65 | CYP3A4 (0.34) | KDM4EALDH1A1HPGDCYP1A2MEN1 | |
| SCHEMBL1338134 | 0.64 | CNR1 (0.33) | HSD11B1ALPLKDM4EALDH1A1HPGD | |
| SCHEMBL11624239 | 0.61 | IDO1 (0.56) | ALPLALDH1A1HPGDMEN1TP53 | |
| SCHEMBL1339221 | 0.59 | HSD11B1 (0.37) | HSD11B1GSK3AGSK3BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |