Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.46 |
| ▸ | APLNR | P35414 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | AGXT | P21549 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1253767 | 0.98 | MEN1 (0.47) | MEN1KMT2AMAPTRAB9AL3MBTL1 | |
| SCHEMBL8878400 | 0.86 | PYCR1 (0.44) | L3MBTL1MAPK1IDO1TAAR1PYCR1 | |
| SCHEMBL12014951 | 0.85 | ACHE (0.52) | MAPTAOC3APLNRLMNANPSR1 | |
| SCHEMBL9145895 | 0.83 | BCL2A1 (0.55) | AOC3APLNRLMNANPSR1IDO1 | |
| SCHEMBL12656069 | 0.83 | AOC3 (0.45) | AOC3APLNRIDO1AGXTTAAR1 | |
| SCHEMBL11052720 | 0.83 | LTA4H (0.53) | MEN1KMT2AAOC3APLNRTDP1 | |
| SCHEMBL31308090 | 0.83 | MEN1 (0.51) | MEN1KMT2AMAPTRAB9AL3MBTL1 | |
| SCHEMBL1871474 | 0.83 | LTA4H (0.53) | AOC3LMNAMAPK1NPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1395379 | 0.83 | NQO1 (0.42) | LMNAMAPK1MAOBALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL9471980 | 0.82 | TAS2R14 (0.44) | MEN1KMT2AMAPTL3MBTL1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068311-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN INHIBITOR | AMIRA PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | claimed |
| US-8772495-B2 | 5-lipoxygenase-activating protein inhibitor | PANMIRA PHARMACEUTICALS, LLC (US) | 2014-07-08 | — | — | US | disclosed |
| US-8772495-B2 | 5-lipoxygenase-activating protein inhibitor | PANMIRA PHARMACEUTICALS, LLC (US) | 2014-07-08 | — | — | US | disclosed |
| US-20120220779-A1 | Novel Processes | GLAXO GROUP LIMITED (GB) | 2012-08-30 | — | — | US | disclosed |
| US-20120220779-A1 | Novel Processes | GLAXO GROUP LIMITED (GB) | 2012-08-30 | — | — | US | disclosed |
| US-20110160249-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN INHIBITOR | AMIRA PHARMACEUTICALS, INC. | 2011-06-30 | — | — | US | disclosed |
| US-20110160249-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN INHIBITOR | AMIRA PHARMACEUTICALS, INC. | 2011-06-30 | — | — | US | disclosed |
| WO-2011054783-A2 | NOVEL PROCESSES | GLAXO GROUP LIMITED (GB) | 2011-05-12 | — | — | WO | disclosed |
| WO-2010068311-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN INHIBITOR | AMIRA PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | disclosed |
| US-20100075934-A1 | 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITOR | AMIRA PHARMACEUTICALS, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100075934-A1 | 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITOR | AMIRA PHARMACEUTICALS, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-20090291981-A1 | 5-Lipoxygenase-Activating Protein Inhibitor | AMIRA PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | US | disclosed |
| US-20090291981-A1 | 5-Lipoxygenase-Activating Protein Inhibitor | AMIRA PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | US | disclosed |
| WO-2009055721-A2 | 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITOR | AMIRA PHARMACEUTICALS, INC. (US) | 2009-04-30 | — | — | WO | disclosed |
| WO-1996037469-A1 | N-BENZYLINDOL-3-YL PROPANIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1996-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075934-A1 | 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITOR | ALOX5, ALOX5AP, LTA4H | MEN1 4436/4885KMT2A 3466/4885MAPT 4613/4885 |
| US-20110160249-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN INHIBITOR | ALOX5, PRMT5, ALOX5AP | MEN1 4039/4885KMT2A 401/4885MAPT 4371/4885 |
| US-20120220779-A1 | Novel Processes | ALOX5, PNPO, ALOX5AP | MEN1 4427/4885KMT2A 3971/4885MAPT 4205/4885 |
| US-20090291981-A1 | 5-Lipoxygenase-Activating Protein Inhibitor | ALOX5, LTA4H, ALOX5AP | MEN1 4560/4885KMT2A 3058/4885MAPT 4693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.