SCHEMBL3140731

SCHEMBL3140731

C#CC(COc1cccc(C(F)(F)F)c1)O[Si](C)(C)C(C)(C)C

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.43
LMNA P02545 1/20 0.41
PKM P14618 1/20 0.41
HSD17B10 Q99714 1/20 0.41
KDM4E B2RXH2 2/20 0.38
ALOX15 P16050 1/20 0.38
ATM Q13315 1/20 0.38
MAOB P27338 2/20 0.38
AOC3 Q16853 1/20 0.38
MAOA P21397 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3140717 1.00 L3MBTL1 (0.43) L3MBTL1LMNAPKMHSD17B10KDM4E
SCHEMBL2497135 0.85 L3MBTL1 (0.48) L3MBTL1LMNAPKMHSD17B10KDM4E
SCHEMBL3147814 0.83 CASR (0.39) LMNA
SCHEMBL3147800 0.83 CASR (0.39) LMNA
SCHEMBL19750656 0.83 LMNA (0.44) L3MBTL1LMNAPKMHSD17B10KDM4E
SCHEMBL6137275 0.82 CYP2D6 (0.42) L3MBTL1LMNAKDM4EMAOBMAOA
SCHEMBL6137281 0.82 CYP2D6 (0.42) L3MBTL1LMNAKDM4EMAOBMAOA
SCHEMBL9794052 0.82 CYP2D6 (0.42) L3MBTL1LMNAKDM4EMAOBMAOA
SCHEMBL9794051 0.81 HTR2A (0.49) LMNAKDM4EMAOB
SCHEMBL9794039 0.81 HTR2A (0.49) LMNAKDM4EMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1169467-B1 PROCESS FOR THE PREPARATION OF PROSTAGLANDIN PRECURSORS CHIROTECH TECHNOLOGY LTD (GB) 2010-02-17 EP disclosed
EP-1169467-A1 PROCESS FOR THE PREPARATION OF PROSTAGLANDIN PRECURSORS Chirotech Technology Limited (GB) 2002-01-09 EP disclosed
US-20010009770-A1 Process for the preparation of prostaglandin precursors FOX MARTIN EDWARD (GB) 2001-07-26 US disclosed
US-6214611-B1 PREPARATION OF A PROPARGYLIC ALCOHOL ENRICHED IN (R)-ENANTIOMER BY ESTERIFICATION OF RACEMIC ALCOHOL USING ACYL DONOR AND ENZYME, REMOVAL OF UNTREATED (S)-ALCOHOL, AND ENANTIOSELECTIVE HYDROLYSIS OF (R)-ESTER USING SECOND ENZYME CHIROTECH TECHNOLOGY LIMITED (GB) 2001-04-10 US disclosed
WO-2000061777-A1 PROCESS FOR THE PREPARATION OF PROSTAGLANDIN PRECURSORS CHIROTECH TECHNOLOGY LIMITED (GB) 2000-10-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010009770-A1 Process for the preparation of prostaglandin precursors ADH1A, ADH1C, ADH5 L3MBTL1 2540/4885LMNA 2426/4885PKM 974/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.