SCHEMBL31411562

SCHEMBL31411562

COC(=O)c1cc2c(s1)SCC(=O)N2Cc1cc(F)cc(C(F)(F)F)c1

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 10/20 0.51
CYP2D6 P10635 1/20 0.37
TSHR P16473 1/20 0.37
CYP3A4 P08684 1/20 0.36
HTT P42858 1/20 0.36
SCN9A Q15858 1/20 0.36
USP2 O75604 2/20 0.36
ALDH1A1 P00352 2/20 0.36
PPARD Q03181 1/20 0.35
PPARA Q07869 1/20 0.35
TP53 P04637 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
MAPT P10636 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31411667 0.90 KCNN4 (0.42) KCNN4TSHRCYP3A4HTTALDH1A1
SCHEMBL31411797 0.78 KCNN4 (0.46) KCNN4CYP2D6TSHRCYP3A4HTT
SCHEMBL31411867 0.78 KCNN4 (0.46) KCNN4CYP2D6TSHRCYP3A4HTT
SCHEMBL31411770 0.77 KCNN4 (0.33) KCNN4SCN9A
SCHEMBL31411665 0.77 KCNN4 (0.42) KCNN4USP2ALDH1A1TP53MAPT
SCHEMBL31411682 0.77 TACR1 (0.35) KCNN4TSHRTP53MAPT
SCHEMBL6996076 0.77 ALDH1A1 (0.41) KCNN4TSHRUSP2ALDH1A1TP53
SCHEMBL31411679 0.76 KCNN4 (0.42) KCNN4USP2ALDH1A1TP53MAPT
SCHEMBL31411767 0.73 ALDH1A1 (0.52) KCNN4CYP2D6CYP3A4ALDH1A1CYP1A2
SCHEMBL31411882 0.73 LMNA (0.38) KCNN4TSHRUSP2ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119330982-A Azetidine compound and medical application thereof 中国科学院上海药物研究所 2025-01-21 CN disclosed