SCHEMBL3141387

SCHEMBL3141387

CNC1(COc2cncc(-c3cccc(NC(C)=O)c3)c2)CC1

nearest known ligand 0.50

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
AKT1 P31749 1/20 0.50
FYN P06241 6/20 0.48
BRAF P15056 4/20 0.48
PIP4K2A P48426 3/20 0.48
PIP4K2B P78356 2/20 0.48
CYP11B2 P19099 2/20 0.47
CYP17A1 P05093 1/20 0.47
CYP11B1 P15538 1/20 0.47
SIRT2 Q8IXJ6 1/20 0.46
SIRT3 Q9NTG7 1/20 0.46
USP7 Q93009 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3782980 0.99 AKT1 (0.49) AKT1FYNBRAFPIP4K2APIP4K2B
SCHEMBL3150823 0.83 FYN (0.41) FYNBRAFCYP11B2CYP17A1CYP11B1
Hydrochloric Acid SCHEMBL3777918 0.82 KMO (0.44)
SCHEMBL3145816 0.82 AKT1 (0.47) AKT1FYNBRAFPIP4K2APIP4K2B
SCHEMBL3145805 0.82 AKT1 (0.49) AKT1FYNBRAFPIP4K2APIP4K2B
Hydrochloric Acid SCHEMBL3151269 0.82 FYN (0.40) FYNCYP11B2CYP17A1CYP11B1USP7
SCHEMBL3142735 0.81 S1PR1 (0.38) CYP11B2CYP11B1
SCHEMBL3150645 0.81 CYP11B1 (0.47) CYP11B2CYP11B1
SCHEMBL3147229 0.81 CHRNB2 (0.49) CYP11B2CYP11B1
SCHEMBL3147306 0.80 INPPL1 (0.43) AKT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1979321-B9 NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SERVIER LAB (FR) 2010-02-17 EP disclosed
EP-1979321-B1 NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SERVIER LAB (FR) 2009-07-29 EP disclosed